Comparison between subjective feelings to alcohol and nitrogen narcosis: A pilot study

Comparison between subjective feelings to alcohol and nitrogen narcosis: A pilot study

Autor Monteiro, M. G. Google Scholar
Hernandez, W. Google Scholar
Figlie, N. B. Google Scholar
Takahashi, E. Google Scholar
Korukian, M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Nitrogen narcosis is often compared to alcohol intoxication, but no actual studies have been carried out in humans to test the comparability of these effects. If a common mechanism of action is responsible for the behavioral effects of these substances, biological variability of response to alcohol should correlate to that of nitrogen in the same individual. To test this hypothesis, subjective feelings were assessed in two separate occasions in 14 adult male, healthy volunteers, nonprofessional divers. in one occasion, each subject received 0.75 ml/kg (0.60 g/kg) alcohol 50% (v/v PO) and in another day underwent a simulated dive at 50 m for 30 min in a hyperbaric chamber. There was a significant correlation between reported feelings in the two sessions; subjects who felt less intoxicated after drinking also felt less nitrogen narcosis during the simulated dive. the results, although preliminary, raise the hypothesis that ethanol and nitrogen may share the same mechanisms of action in the brain and that biological differences might account for interindividual variability of responses to both ethanol and nitrogen.
Palavra-chave ethanol
nitrogen narcosis
genetic differences
intoxication
hyperbaric environment
Idioma Inglês
Data de publicação 1996-01-01
Publicado em Alcohol. Oxford: Pergamon-Elsevier B.V., v. 13, n. 1, p. 75-78, 1996.
ISSN 0741-8329 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 75-78
Fonte http://dx.doi.org/10.1016/0741-8329(95)02016-0
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996TW35000015
Endereço permanente http://repositorio.unifesp.br/handle/11600/25551

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