Monovalent latex agglutination reagents for the diagnosis of nonmeningitic pneumococcal infection

Monovalent latex agglutination reagents for the diagnosis of nonmeningitic pneumococcal infection

Autor Harrison, L. H. Google Scholar
Steinhoff, M. C. Google Scholar
Sridharan, G. Google Scholar
Castelo, A. Google Scholar
Khallaf, N. Google Scholar
Ostroff, S. M. Google Scholar
Arthur, R. R. Google Scholar
Instituição JOHNS HOPKINS UNIV
Universidade Federal de São Paulo (UNIFESP)
MINIST HLTH CAIRO
CTR DIS CONTROL & PREVENT
Resumo The pneumococcus is a leading cause of serious bacterial infection worldwide. Given the difficulties with available assays for the diagnosis of invasive nonmeningitic pneumococcal infection, we evaluated monovalent slide latex agglutinatio reagents among patients with blood culture-confirmed pneumococcal infection and control patients in Baltimore, Maryland, USA; São Paulo, Brazil; and Cairo, Egypt. Among 50 patients with invasive nonmeningitic pneumococcal infection, 23 had a positive urine test for a sensitivity of 46% (95% confidence intervals of 32% and 61%). Among 39 healthy children, 36 had a negative assay, for a specificity of 92% (95% confidence intervals of 78% and 98%). Among 80 children with pneumonia without a positive blood culture for Streptococcus pneumoniae, the specificity was 88% (95% confidence intervals of 78% and 94%). Although the assay was fairly specific, the positive predictive value using optimistic assumptions was only 73%-83%. This study suggests that this assay has a sensitivity and positive predictive value that may limit its value in some settings.
Idioma Inglês
Data de publicação 1996-01-01
Publicado em Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 24, n. 1, p. 1-6, 1996.
ISSN 0732-8893 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1-6
Fonte http://dx.doi.org/10.1016/0732-8893(95)00255-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996UB88400001
Endereço permanente http://repositorio.unifesp.br/handle/11600/25550

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