Extracellular and intracellular degradation of collagen by trophoblast giant cells in acute fasted mice examined by electron microscopy

Extracellular and intracellular degradation of collagen by trophoblast giant cells in acute fasted mice examined by electron microscopy

Autor Katz, S. G. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The fine structure of trophoblast giant cells and their interaction with collagen at the antimesometrial region on the 9th day of pregnancy was examined in fed and acute fasted mice, Collagen fibrils and filamentous aggregates (disintegrating collagen fibrils) were observed in the extracellular space, Three types of intracellular vacuoles containing collagen fibrils were present: vacuole type A exhibited typical cross-banded collagen immersed in finely granular electron-translucent material; and vacuoles type B and C showed electron-opaque granular material containing, respectively, faint cross-banded collagen and narrow clear stripes often with faint periodicity, in fed animals vacuoles type B were absent and the others were less evident.Only fasted animals showed extracellular acid phosphatase activity on collagen fibrils, filamentous aggregates and confined regions of the extracellular space. Intracellular acid phosphatase activity was observed in vacuoles type B and in lysosomes.The results indicate that trophoblast giant cells are capable of breaking down extracellular collagen and also of internalizing collagen for intracellular degradation, It is likely that these events are part of the process of invasion of the uterine wall, However, in fasted mice, collagen breakdown is more pronounced, and it may therefore contribute to the provision of amino acids and other nutrients for the undernourished fetus.
Palavra-chave trophoblast
collagen
fasting
pregnancy
electron microscopy
mouse
Idioma Inglês
Data de publicação 1995-12-01
Publicado em Tissue & Cell. Edinburgh: Churchill Livingstone, v. 27, n. 6, p. 713-721, 1995.
ISSN 0040-8166 (Sherpa/Romeo, fator de impacto)
Publicador Churchill Livingstone
Extensão 713-721
Fonte http://dx.doi.org/10.1016/S0040-8166(05)80026-6
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995TN61800011
Endereço permanente http://repositorio.unifesp.br/handle/11600/25543

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