Action of papain, sugar, minoxidil, and glucan on excisional wounds in rats

Action of papain, sugar, minoxidil, and glucan on excisional wounds in rats

Author Brenda, E. Google Scholar
Marques, A. Google Scholar
Saldiva, PHN Google Scholar
Hidalgo, G. S. Google Scholar
Goldenberg, S. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
HOSP AC CAMARGO ANTONIO PRUDENTE FDN
Abstract Four topical drugs were studied with regard to their ability to promote healing of open wounds in 60 Wistar rats. Five study groups were defined. Four of the five groups received one of the following substances: papain, sugar, minoxidil, or glucan. the fifth group or control group received saline solution (NaCl, 0.9%). An experimental model with wound standardization (6 x 3.5 cm) was used. the raw area and new epithelium were quantified in each rat by taking photographs from which planimetry was performed. the closure of the first lesion occurred on the 49th postoperative day. Quantitative assessment of collagen deposition was performed using image analyzing software on slides stained with picrosirius and observed under polarized light. Epithelium formation was greatest in the minoxidil group, followed (in decreasing order) by the sugar, papain, control, and glucan groups. Significant differences in collagen deposition were observed among all the groups. the greatest amount of collagen was quantified in the glucan group, followed (in decreasing order) by the sugar, minoxidil, papain, and control groups. This data and possible mechanisms for the interference of each substance in wound healing are considered.
Language English
Date 1995-12-01
Published in Current Therapeutic Research-clinical and Experimental. New York: Excerpta Medica Inc, v. 56, n. 12, p. 1285-1297, 1995.
ISSN 0011-393X (Sherpa/Romeo, impact factor)
Publisher Excerpta Medica Inc
Extent 1285-1297
Origin http://dx.doi.org/10.1016/0011-393X(95)85073-2
Access rights Closed access
Type Article
Web of Science ID WOS:A1995TN60200008
URI http://repositorio.unifesp.br/handle/11600/25541

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