The influence of isotonic exercise on cardiac-hypertrophy in arterial-hypertension - impact on cardiac-function and on the capacity for aerobic work

The influence of isotonic exercise on cardiac-hypertrophy in arterial-hypertension - impact on cardiac-function and on the capacity for aerobic work

Autor Moreno, H. Google Scholar
Cezareti, MLR Google Scholar
Piçarro, Ivan da Cruz Autor UNIFESP Google Scholar
Neto, TLB Google Scholar
Martinez, E. E. Google Scholar
Saragoca, MAS Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Intense physical training through isotonic exercises has controversial effects in individuals with moderate to severe hypertension, in this study, normotensive Wistar rats and rats with renovascular hypertension (Goldblatt II) were subjected to intense physical exercise involving two 50-min swimming sessions per day for a period of 12 weeks, At the end of the study, we evaluated the effect of training on arterial pressure, the capacity for aerobic work and cardiac function. Our results demonstrate that intense physical training has no effect on the arterial blood pressure of normotensive rats or of animals with moderate renovascular hypertension, Hypertensive animals with cardiac hypertrophy require a greater period of training in order to attain the same capacity for aerobic work as normotensive rats. This difference may result from an inability of the former animals to increase cardiac compliance, thereby impeding more extensive usage of the Frank-Starling mechanism to subsequently increase the systolic cardiac performance, Cardiac hypertrophy induced by exercise did not summate with that induced by arterial hypertension, Physical exercise normalized the end-diastolic left ventricular pressure in hypertensive animals without any corresponding increase in the compliance of the chamber, the first derivative of left ventricular pulse pressure (+/-dP/dt) was greater in the hypertensive trained group than in the hypertensive sedentary rats, These observations suggest that a systolic dysfunction of the left ventricle involving an elevated residual volume secondary to arterial hypertension may be corrected by physical exercise such as swimming.
Palavra-chave LEFT VENTRICULAR HYPERTROPHY
PHYSICAL TRAINING
ARTERIAL HYPERTENSION
OXYGEN CONSUMPTION
CARDIAC COMPLIANCE
Idioma Inglês
Data de publicação 1995-10-01
Publicado em Comparative Biochemistry and Physiology A-physiology. Oxford: Pergamon-Elsevier B.V., v. 112, n. 2, p. 313-320, 1995.
ISSN 0300-9629 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 313-320
Fonte http://dx.doi.org/10.1016/0300-9629(95)00103-4
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995TB71900007
Endereço permanente http://repositorio.unifesp.br/handle/11600/25529

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