THE ANTIMENINGOCOCCAL VACCINE VAMENGOC B-C INDUCED POOR SERUM and SALIVARY ANTIBODY-RESPONSE in YOUNG BRAZILIAN CHILDREN

THE ANTIMENINGOCOCCAL VACCINE VAMENGOC B-C INDUCED POOR SERUM and SALIVARY ANTIBODY-RESPONSE in YOUNG BRAZILIAN CHILDREN

Autor Carbonare, S. B. Google Scholar
Arslanian, C. Google Scholar
Silva, MLM Google Scholar
Farhat, C. K. Google Scholar
Carneirosampaio, MMS Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo In 1989 about 2.3 million Brazilian children received the antimeningococcal vaccine VAMEN-GOC B-C (Havana, Cuba). We evaluated the serum and secretory immune response of vaccinated children by enzyme-linked immunosorbent assay with outer membrane complex antigens. Western blotting and bacterial adherence inhibition assays with human buccal epithelial cells were performed with some of the samples. Serum and salivary antibody concentrations to Neisseria meningitidis Group B of vaccinated children <4 years old were not significantly higher than those of nonvaccinated children, as observed in convalescing patients used as positive controls. Older children (4 to 6 years old) presented a slight increase in antibody OD indexes. Sera and saliva from vaccinated children showed a weak reaction with meningococcal antigen by Western blotting and were unable to inhibit significantly the adherence of N. meningitidis B to buccal epithelial cells. These data suggest that this vaccine induced a poor serum and salivary antibody response in the population studied.
Palavra-chave MENINGITIS
NEISSERIA MENINGITIDIS
ANTIMENINGOCOCCAL VACCINE
BACTERIAL ADHESION
SALIVARY ANTIBODIES
SECRETORY ANTIBODIES
SERUM ANTIBODIES
Idioma Inglês
Data de publicação 1995-09-01
Publicado em Pediatric Infectious Disease Journal. Baltimore: Williams & Wilkins, v. 14, n. 9, p. 797-803, 1995.
ISSN 0891-3668 (Sherpa/Romeo, fator de impacto)
Publicador Williams & Wilkins
Extensão 797-803
Fonte http://dx.doi.org/10.1097/00006454-199509000-00013
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995RU93200012
Endereço permanente http://repositorio.unifesp.br/handle/11600/25527

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