THE PORTAL HYPERTENSIVE RESPONSE TO BRADYKININ IS MEDIATED BY the B2-TYPE RECEPTOR and MODULATED BY NITRIC-OXIDE

THE PORTAL HYPERTENSIVE RESPONSE TO BRADYKININ IS MEDIATED BY the B2-TYPE RECEPTOR and MODULATED BY NITRIC-OXIDE

Autor Loureirosilva, M. R. Google Scholar
Molina, H. M. Google Scholar
Borges, D. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Using the in situ perfusion of the isolated and exsanguinated rat liver we studied: (1) the effect of des-Arg(9)[Leu(8)]-bradykinin and HOE-140, B1- and B2-type bradykinin receptor antagonists, respectively, on the portal hypertensive response (PHR) to bradykinin (BK) or to kallidin (Lys-BK); and (2) the effect of Nw-nitro-L-arginine (NNLA), a nitric oxide synthase inhibitor, on the PHR to BK. We observed that: (1) des-Arg(9)[Leu(8)]-BK does not change the PHR either to BK or to Lys-BK; (2) HOE-140 abolishes the PHR to both BK and Lys-BK; and (3) the presence of NNLA increases the PHR to BK. We conclude that the PHR to BK is mediated by the B2-type receptor and that this response is modulated by NO, which maintains a vasodilatory tonus on the portal system.
Palavra-chave HOE-140
KININ
L-ARGININE-NITRIC OXIDE PATHWAY
N-OMEGA-NITRO-L-ARGININE
PORTAL SYSTEM
LIVER VASCULATURE
Idioma Inglês
Data de publicação 1995-09-01
Publicado em International Hepatology Communications. Clare: Elsevier Sci Publ Ireland Ltd, v. 4, n. 3, p. 175-180, 1995.
ISSN 0928-4346 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 175-180
Fonte http://dx.doi.org/10.1016/0928-4346(95)00243-X
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995TH17400010
Endereço permanente http://repositorio.unifesp.br/handle/11600/25524

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