PARTICIPATION of the ADRENAL-GLAND in the ANTIINFLAMMATORY EFFECT of POLYUNSATURATED DIETS

PARTICIPATION of the ADRENAL-GLAND in the ANTIINFLAMMATORY EFFECT of POLYUNSATURATED DIETS

Autor Silveira, Vera Lucia Flor Autor UNIFESP Google Scholar
Limaos, E. A. Google Scholar
Nunes, D. W. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo THE effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and alpha(2)-macroglobulin (alpha(2)-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a diet rich in fish oil but also in the soybean group. alpha(2)-M was not detectable before carrageenin injection, suggesting that this putative anti-inflammatory factor does not participate in the observed anti-inflammatory effect. Corticosterone levels were higher in fat-fed than in control rats, before carrageenin stimulus and adrenalectomy abolished the anti-inflammatory response in fat-fed animals, showing the important role of the adrenocortical hormones in this process.
Assunto CARRAGEENAN EDEMA
CORTICOSTEROIDS
ALPHA(2)-MACROGLOBULIN
POLYUNSATURATED FATTY ACIDS
Idioma Inglês
Data 1995-09-01
Publicado em Mediators of Inflammation. London: Rapid Science Publishers, v. 4, n. 5, p. 359-363, 1995.
ISSN 0962-9351 (Sherpa/Romeo, fator de impacto)
Editor Rapid Science Publishers
Extensão 359-363
Fonte http://dx.doi.org/10.1155/S0962935195000585
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1995TC00200008
URI http://repositorio.unifesp.br/handle/11600/25522

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