PROLONGED TREATMENT WITH CARBAMAZEPINE INCREASES the STIMULATORY EFFECTS of ETHANOL in MICE

PROLONGED TREATMENT WITH CARBAMAZEPINE INCREASES the STIMULATORY EFFECTS of ETHANOL in MICE

Autor Camarini, R. Google Scholar
Andreatini, R. Google Scholar
Monteiro, M. G. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Carbamazepine (CBZ) has been used in the treatment of alcohol withdrawal (AW). However, cases of induction of euphoric feelings when mixed with alcohol have been reported. We verified whether CBZ could potentiate ethanol stimulatory effects in animals. Two groups of mice were injected with saline (group I) or 2 g/kg ethanol (group II) IF, for 20 days. On the next day, each group was divided into two subgroups that received either a single dose of CBZ (10 mg/kg) or vehicle IF, followed, 30 min later, by saline or ethanol injection. Locomotor activity was measured. Acute CBZ did not change locomotor activity of ethanol-treated mice. Treatment with CBZ or vehicle continued for 6 days. Finally, on the 28th day, 30 min after the last CBZ or vehicle injection, an ethanol challenge was given to group II and a saline injection to group I. the results showed a significant potentiation of ethanol stimulatory effects by chronic CBZ treatment. Data indicated that CBZ should be cautiously administered to alcohol-dependent patients.
Palavra-chave ALCOHOL
CARBAMAZEPINE
STIMULATORY EFFECTS
SENSITIZATION
LOCOMOTOR ACTIVITY
MICE
Idioma Inglês
Data de publicação 1995-07-01
Publicado em Alcohol. Oxford: Pergamon-Elsevier B.V., v. 12, n. 4, p. 305-308, 1995.
ISSN 0741-8329 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 305-308
Fonte http://dx.doi.org/10.1016/0741-8329(95)00002-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995RM00600002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25512

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