A COMPARATIVE-STUDY ON the MECHANISM of the ANTICOAGULANT ACTION of MOLLUSK and MAMMALIAN HEPARINS

A COMPARATIVE-STUDY ON the MECHANISM of the ANTICOAGULANT ACTION of MOLLUSK and MAMMALIAN HEPARINS

Autor Paiva, J. F. Google Scholar
Santos, E. A. Google Scholar
Jeske, W. Google Scholar
Fareed, J. Google Scholar
Nader, H. B. Google Scholar
Dietrich, C. P. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The anticlotting activities on some steps of the coagulation cascade of mollusc and mammalian heparins were studied. AT III-high affinity heparin is a more potent inhibitor than unfractionated heparin and mollusc heparin in the intrinsic and extrinsic pathways of thrombin and factor Xa generation. Mollusan heparin has about the same activity as the AT III high affinity-heparin on the inhibition of factor Xa and thrombin in the presence of antithrombin III and four times more inhibitory activity than unfractionated heparin on the heparin cofactor II mediated inhibition of thrombin.
Palavra-chave MOLLUSK HEPARIN
COAGULATION FACTORS
ANTITHROMBIN III ACTION
HEPARIN COFACTOR II
ACTION in the COAGULATION CASCADE
INTRINSIC and EXTRINSIC MEDIATED INHIBITION of THROMBIN
Idioma Inglês
Data de publicação 1995-07-01
Publicado em Comparative Biochemistry and Physiology A-physiology. Oxford: Pergamon-Elsevier B.V., v. 111, n. 3, p. 495-499, 1995.
ISSN 0300-9629 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 495-499
Fonte http://dx.doi.org/10.1016/0300-9629(94)00021-K
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995RF80500021
Endereço permanente http://repositorio.unifesp.br/handle/11600/25511

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta