PARADOXICAL SLEEP-DEPRIVATION in FEMALE RATS ALTERS DRUG-INDUCED BEHAVIORS

PARADOXICAL SLEEP-DEPRIVATION in FEMALE RATS ALTERS DRUG-INDUCED BEHAVIORS

Autor Hipolide, D. C. Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Paradoxical sleep deprivation (PSD) induces changes in behaviors induced by dopaminergic and cholinergic agonists, including increased aggressive behavior and stereotypy, decreased number of yawns, and shedding of bloody tears in male rats. in female rats, however, very little is known about the relationship between PSD and the effect of these drugs. the present study sought to examine this issue. As in males, PSD in females resulted in increased apomorphine-induced stereotypy, decreased pilocarpine-induced chromodacryorrhea, and hyperthermia. Unlike males, however, no apomorphine-induced aggressiveness or apomorphine- and pilocarpine-induced yawning were observed in PSD females. These findings suggest that female sexual hormones may affect the expression of some behaviors and not the neurotransmission as a whole, because drug-induced behaviors in PSD females were partly similar to those observed in PSD males.
Assunto PARADOXICAL SLEEP DEPRIVATION
FEMALES
DOPAMINERGIC SYSTEM
STEREOTYPY
AGGRESSIVENESS
YAWNING
Idioma Inglês
Data 1995-06-01
Publicado em Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 57, n. 6, p. 1139-1143, 1995.
ISSN 0031-9384 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 1139-1143
Fonte http://dx.doi.org/10.1016/0031-9384(94)00377-H
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995QY76400019
URI http://repositorio.unifesp.br/handle/11600/25500

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