EFFECTS of MONOSIALOGANGLIOSIDE ON DOPAMINERGIC SUPERSENSITIVITY

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dc.contributor.author Vital, MABF
dc.contributor.author Frussafilho, R.
dc.contributor.author Palermoneto, J.
dc.date.accessioned 2016-01-24T11:40:24Z
dc.date.available 2016-01-24T11:40:24Z
dc.date.issued 1995-05-19
dc.identifier http://dx.doi.org/10.1016/0024-3205(95)00224-T
dc.identifier.citation Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 56, n. 26, p. 2299-2307, 1995.
dc.identifier.issn 0024-3205
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25495
dc.description.abstract The effects of monosialoganglioside (GM(1)) treatment on dopaminergic supersensitivity induced by long-term haloperidol administration were studied; both general activity of rats observed in an open-field and apomorphine-induced stereotyped behavior were used as experimental parameters. GM(1) per se (5.0 mg/kg, twice daily, for 30 days) did not modify rat behavior, but when given in combination with haloperidol (1.0 mg/kg, twice daily, for 30 days) it increased neuroleptic withdrawal symptoms as detected in both models. When GM(1) (5.0 mg/kg, twice daily) was administered after abrupt withdrawal from haloperidol (1.0 mg/kg, twice daily, for 30 days), it attenuated the increases in both general activity of rats observed in the open-field and apomorphine-induced stereotyped behavior. These results suggest that GM(1) may affect synaptic plasticity, facilitating the induction of the adaptative changes in receptor function (up and down-regulation), following long-term haloperidol treatment and withdrawal. en
dc.format.extent 2299-2307
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Life Sciences
dc.rights Acesso restrito
dc.subject HALOPERIDOL en
dc.subject GANGLIOSIDES en
dc.subject DOPAMINERGIC SUPERSENSITIVITY en
dc.subject GM(1) en
dc.subject DRUG WITHDRAWAL en
dc.title EFFECTS of MONOSIALOGANGLIOSIDE ON DOPAMINERGIC SUPERSENSITIVITY en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation UNIV São Paulo,SCH VET MED,APPL PHARMACOL & TOXICOL LAB,São Paulo,BRAZIL
dc.description.affiliation ESCOLA PAULISTA MED,DEPT PHARMACOL,São Paulo,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED,DEPT PHARMACOL,São Paulo,BRAZIL
dc.identifier.doi 10.1016/0024-3205(95)00224-T
dc.description.source Web of Science
dc.identifier.wos WOS:A1995QZ86500002



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