EFFECTS of MONOSIALOGANGLIOSIDE ON DOPAMINERGIC SUPERSENSITIVITY

EFFECTS of MONOSIALOGANGLIOSIDE ON DOPAMINERGIC SUPERSENSITIVITY

Autor Vital, MABF Google Scholar
Frussafilho, R. Google Scholar
Palermoneto, J. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The effects of monosialoganglioside (GM(1)) treatment on dopaminergic supersensitivity induced by long-term haloperidol administration were studied; both general activity of rats observed in an open-field and apomorphine-induced stereotyped behavior were used as experimental parameters. GM(1) per se (5.0 mg/kg, twice daily, for 30 days) did not modify rat behavior, but when given in combination with haloperidol (1.0 mg/kg, twice daily, for 30 days) it increased neuroleptic withdrawal symptoms as detected in both models. When GM(1) (5.0 mg/kg, twice daily) was administered after abrupt withdrawal from haloperidol (1.0 mg/kg, twice daily, for 30 days), it attenuated the increases in both general activity of rats observed in the open-field and apomorphine-induced stereotyped behavior. These results suggest that GM(1) may affect synaptic plasticity, facilitating the induction of the adaptative changes in receptor function (up and down-regulation), following long-term haloperidol treatment and withdrawal.
Palavra-chave HALOPERIDOL
GANGLIOSIDES
DOPAMINERGIC SUPERSENSITIVITY
GM(1)
DRUG WITHDRAWAL
Idioma Inglês
Data de publicação 1995-05-19
Publicado em Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 56, n. 26, p. 2299-2307, 1995.
ISSN 0024-3205 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 2299-2307
Fonte http://dx.doi.org/10.1016/0024-3205(95)00224-T
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995QZ86500002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25495

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