CHRONIC EFFECTS of AZIDOTHYMIDINE and ACYCLOVIR ON PREGNANT RATS

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dc.contributor.author Mamede, JAV
dc.contributor.author Simoes, MDJ
dc.contributor.author Novo, N. F.
dc.contributor.author Juliano, Y.
dc.contributor.author Oliveira, R. M.
dc.contributor.author Kulay, L.
dc.date.accessioned 2016-01-24T11:40:24Z
dc.date.available 2016-01-24T11:40:24Z
dc.date.issued 1995-05-01
dc.identifier http://dx.doi.org/10.1016/0306-3623(94)00237-H
dc.identifier.citation General Pharmacology. Oxford: Pergamon-Elsevier B.V., v. 26, n. 3, p. 523-526, 1995.
dc.identifier.issn 0306-3623
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25492
dc.description.abstract 1. the antiviral effect of azidothymidine (AZT) can be potentiated by acyclovir (ACV), and this drug association has been used in the management of HIV-infected patients. in the present study we examined the effects of such an association on rat pregnancy.2. AZT (60 mg/kg b.w.) and ACV (60 mg/kg b.w.) were given to groups of pregnant rats once a day from the 1st to the 20th day of gestation.3. Maternal body weight gain was severely affected by ACV; this effect was attenuated in rats treated with AZT + ACV and was virtually absent with AZT alone.4. the abortive action of ACV was markedly diminished in the group treated with the association AZT + ACV.5. the deleterious effects of ACV on rat pregnancy are presumably due to its extraplacental actions, and these are, at least in part, counteracted by concomitant treatment with AZT. en
dc.format.extent 523-526
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof General Pharmacology
dc.rights Acesso restrito
dc.subject AZIDOTHYMIDINE en
dc.subject ACYCLOVIR en
dc.subject PREGNANT RATS en
dc.title CHRONIC EFFECTS of AZIDOTHYMIDINE and ACYCLOVIR ON PREGNANT RATS en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation ESCOLA PAULISTA MED,DEPT OBSTET & GYNECOL,RUA BOTUCATU,740 VILA CLEMENTINO,BR-04023000 São Paulo,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED,DEPT OBSTET & GYNECOL,RUA BOTUCATU,740 VILA CLEMENTINO,BR-04023000 São Paulo,BRAZIL
dc.identifier.doi 10.1016/0306-3623(94)00237-H
dc.description.source Web of Science
dc.identifier.wos WOS:A1995QQ05500010



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