CHRONIC EFFECTS of AZIDOTHYMIDINE and ACYCLOVIR ON PREGNANT RATS

CHRONIC EFFECTS of AZIDOTHYMIDINE and ACYCLOVIR ON PREGNANT RATS

Author Mamede, JAV Google Scholar
Simoes, MDJ Google Scholar
Novo, N. F. Google Scholar
Juliano, Y. Google Scholar
Oliveira, R. M. Google Scholar
Kulay, L. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract 1. the antiviral effect of azidothymidine (AZT) can be potentiated by acyclovir (ACV), and this drug association has been used in the management of HIV-infected patients. in the present study we examined the effects of such an association on rat pregnancy.2. AZT (60 mg/kg b.w.) and ACV (60 mg/kg b.w.) were given to groups of pregnant rats once a day from the 1st to the 20th day of gestation.3. Maternal body weight gain was severely affected by ACV; this effect was attenuated in rats treated with AZT + ACV and was virtually absent with AZT alone.4. the abortive action of ACV was markedly diminished in the group treated with the association AZT + ACV.5. the deleterious effects of ACV on rat pregnancy are presumably due to its extraplacental actions, and these are, at least in part, counteracted by concomitant treatment with AZT.
Keywords AZIDOTHYMIDINE
ACYCLOVIR
PREGNANT RATS
Language English
Date 1995-05-01
Published in General Pharmacology. Oxford: Pergamon-Elsevier B.V., v. 26, n. 3, p. 523-526, 1995.
ISSN 0306-3623 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 523-526
Origin http://dx.doi.org/10.1016/0306-3623(94)00237-H
Access rights Closed access
Type Article
Web of Science ID WOS:A1995QQ05500010
URI http://repositorio.unifesp.br/handle/11600/25492

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