ENVIRONMENTAL TRANSMISSION of HEPATITIS-B and HEPATITIS-C VIRUSES WITHIN the HEMODIALYSIS UNIT

ENVIRONMENTAL TRANSMISSION of HEPATITIS-B and HEPATITIS-C VIRUSES WITHIN the HEMODIALYSIS UNIT

Autor Neto, M. C. Google Scholar
Manzano, SIR Google Scholar
Canziani, M. E. Google Scholar
Silva, AEB Google Scholar
Cirenza, MLF Google Scholar
Sesso, R. D. Google Scholar
Ajzen, H. Google Scholar
Draibe, S. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The hepatitis B virus (HBV) can be transmitted in the dialysis setting through blood transfusions and environmental surfaces. Transfusion related hepatitis C virus (HCV) infection is very well known, but only recently the environmental transmission of this virus was postulated, in order to study the prevalence, mechanisms of transmission, and the ALT patterns of HBV and HCV infections in hemodialysis and CAPD patients before the implementation of HBV vaccination and HCV screening in the blood bank, we conducted a study from January 1987 to January 1990, Sera from 185 hemodialysis and 124 CAPD patients were stored in this period and later analyzed for HBsAg, anti-HBc, anti-HBs, and anti-HCV (second generation ELISA). the prevalence of any HBV marker was 55.7% (103/185) for hemodialysis patients and 31.5% (39/124) for CAPD patients (hemodialysis vs. CAPD, p < 0.001). the prevalence of positive anti-HCV was 35.1% (65/185) for hemodialysis and 33.9% (42/124) for CAPD patients (not significant). There was a significant association between HBV markers positivity and anti-HCV positivity. the multivariate analysis of risk factors revealed an association of the positivity of each virus with the duration of renal replacement therapy (RRT), number of previous blood transfusions, and past history of hemodialysis treatment. Thus, besides the transfusion-related transmission, hemodialysis environmental transmission may also occur for both viruses. the findings of a high prevalence of both viruses and evidence for environmental transmission in the dialysis setting are of major importance for the planning of future preventive measures.
Palavra-chave HEPATITIS B
HEPATITIS C
HEMODIALYSIS
CAPD
TRANSMISSION
TRANSFUSION
Idioma Inglês
Data de publicação 1995-03-01
Publicado em Artificial Organs. Cambridge: Blackwell Science Publ Inc Cambridge, v. 19, n. 3, p. 251-255, 1995.
ISSN 0160-564X (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Science Publ Inc Cambridge
Extensão 251-255
Fonte http://dx.doi.org/10.1111/j.1525-1594.1995.tb02323.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995QN48700012
Endereço permanente http://repositorio.unifesp.br/handle/11600/25476

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