RENIN-ALDOSTERONE AXIS in NORMOALBUMINURIC INSULIN-DEPENDENT DIABETES-MELLITUS PATIENTS WITH GLOMERULAR HYPERFILTRATION

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dc.contributor.author Deazevedo, M. J.
dc.contributor.author Ramos, O. L.
dc.contributor.author Gross, J. L.
dc.date.accessioned 2016-01-24T11:40:22Z
dc.date.available 2016-01-24T11:40:22Z
dc.date.issued 1995-03-01
dc.identifier http://dx.doi.org/10.1016/0168-8227(95)01047-H
dc.identifier.citation Diabetes Research and Clinical Practice. Clare: Elsevier Sci Publ Ireland Ltd, v. 27, n. 3, p. 205-210, 1995.
dc.identifier.issn 0168-8227
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25472
dc.description.abstract The renin-aldosterone axis was evaluated by captopril test in 22 normotensive normoalbuminuric insulin-dependent diabetes mellitus (IDDM) patients with and without glomerular hyperfiltration. Patients were divided into those with glomerular hyperfiltration (Hf-IDDM) and with normal glomerular filtration rate (GFR; Nf-IDDM) according to the upper limit of GFR (134.7 ml/min per 1.73 m(2)). sixteen normal individuals were also studied. GFR was measured by the Cr-51-EDTA single injection method, extracellular fluid volume as the distribution volume of Cr-51-EDTA, and blood volume using Cr-51-sodium chromate-labelled red blood cells. Twenty-five mg of captopril were administered per os and plasma renin activity (PRA; RIA), plasma aldosterone (RIA) and blood pressure were measured at 0 and 120 min post-captopril. PRA at time zero (Hf-IDDM = 2.4 +/- 1.7; Nf-IDDM = 2.5 +/- 1.9; controls = 1.0 +/- 0.6 ng/ml/h) and at 120 min (Hf-IDDM = 9.9 +/- 8.3; Nf-IDDM = 11.2 +/- 8.9; controls = 5.4 +/- 5.7 ng/ml/h) was higher in IDDM patients than in controls (P = 0.01). the increase of PRA was similar in patients (Hf-IDDM = 7.5 +/- 7.3, and Nf-IDDM = 8.7 +/- 7.2 ng/ml/h) and controls (4.4 +/- 5.3 ng/ml/h). There was no difference in PRA levels between Hf-IDDM and Nf-IDDM patients. PRA did not correlate with GFR, aldosterone, blood pressure, blood volume, duration of diabetes, 24-h urinary sodium and metabolic control indexes. Plasma aldosterone and the magnitude of its decrease after captopril was similar among patients and controls. Captopril induced a greater reduction of systolic blood pressure in patients (Hf-IDDM = 12.3 +/- 6.9 mmHg; Nf-IDDM = 11.1 +/- 7.3 mmHg) than in controls (5.4 +/- 5.2 mmHg) (P = 0.01). No difference was found between Hf-IDDM and Nf-IDDM patients. in conclusion, normoalburninuric IDDM patients, irrespective of glomerular hyperfiltration, presented increased levels of PRA and larger blood pressure response to captopril as compared to normal individuals. en
dc.format.extent 205-210
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Diabetes Research and Clinical Practice
dc.rights Acesso restrito
dc.subject RENIN-ALDOSTERONE AXIS en
dc.subject INSULIN-DEPENDENT DIABETES MELLITUS en
dc.subject GLOMERULAR HYPERFILTRATION en
dc.subject CAPTOPRIL en
dc.title RENIN-ALDOSTERONE AXIS in NORMOALBUMINURIC INSULIN-DEPENDENT DIABETES-MELLITUS PATIENTS WITH GLOMERULAR HYPERFILTRATION en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution UNIV FED RIO GRANDE SUL
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation UNIV FED RIO GRANDE SUL,HOSP CLIN PORTO ALEGRE,PESAUIA & PAS GRAD GRP,ENDOCRINE UNIT,BR-90035003 PORTO ALEGRE,RS,BRAZIL
dc.description.affiliation ESCOLA PAULISTA MED,NEPHROL UNIT,São Paulo,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED,NEPHROL UNIT,São Paulo,BRAZIL
dc.identifier.doi 10.1016/0168-8227(95)01047-H
dc.description.source Web of Science
dc.identifier.wos WOS:A1995RL00200008



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