RENIN-ALDOSTERONE AXIS in NORMOALBUMINURIC INSULIN-DEPENDENT DIABETES-MELLITUS PATIENTS WITH GLOMERULAR HYPERFILTRATION

RENIN-ALDOSTERONE AXIS in NORMOALBUMINURIC INSULIN-DEPENDENT DIABETES-MELLITUS PATIENTS WITH GLOMERULAR HYPERFILTRATION

Autor Deazevedo, M. J. Google Scholar
Ramos, O. L. Google Scholar
Gross, J. L. Google Scholar
Instituição UNIV FED RIO GRANDE SUL
Universidade Federal de São Paulo (UNIFESP)
Resumo The renin-aldosterone axis was evaluated by captopril test in 22 normotensive normoalbuminuric insulin-dependent diabetes mellitus (IDDM) patients with and without glomerular hyperfiltration. Patients were divided into those with glomerular hyperfiltration (Hf-IDDM) and with normal glomerular filtration rate (GFR; Nf-IDDM) according to the upper limit of GFR (134.7 ml/min per 1.73 m(2)). sixteen normal individuals were also studied. GFR was measured by the Cr-51-EDTA single injection method, extracellular fluid volume as the distribution volume of Cr-51-EDTA, and blood volume using Cr-51-sodium chromate-labelled red blood cells. Twenty-five mg of captopril were administered per os and plasma renin activity (PRA; RIA), plasma aldosterone (RIA) and blood pressure were measured at 0 and 120 min post-captopril. PRA at time zero (Hf-IDDM = 2.4 +/- 1.7; Nf-IDDM = 2.5 +/- 1.9; controls = 1.0 +/- 0.6 ng/ml/h) and at 120 min (Hf-IDDM = 9.9 +/- 8.3; Nf-IDDM = 11.2 +/- 8.9; controls = 5.4 +/- 5.7 ng/ml/h) was higher in IDDM patients than in controls (P = 0.01). the increase of PRA was similar in patients (Hf-IDDM = 7.5 +/- 7.3, and Nf-IDDM = 8.7 +/- 7.2 ng/ml/h) and controls (4.4 +/- 5.3 ng/ml/h). There was no difference in PRA levels between Hf-IDDM and Nf-IDDM patients. PRA did not correlate with GFR, aldosterone, blood pressure, blood volume, duration of diabetes, 24-h urinary sodium and metabolic control indexes. Plasma aldosterone and the magnitude of its decrease after captopril was similar among patients and controls. Captopril induced a greater reduction of systolic blood pressure in patients (Hf-IDDM = 12.3 +/- 6.9 mmHg; Nf-IDDM = 11.1 +/- 7.3 mmHg) than in controls (5.4 +/- 5.2 mmHg) (P = 0.01). No difference was found between Hf-IDDM and Nf-IDDM patients. in conclusion, normoalburninuric IDDM patients, irrespective of glomerular hyperfiltration, presented increased levels of PRA and larger blood pressure response to captopril as compared to normal individuals.
Palavra-chave RENIN-ALDOSTERONE AXIS
INSULIN-DEPENDENT DIABETES MELLITUS
GLOMERULAR HYPERFILTRATION
CAPTOPRIL
Idioma Inglês
Data de publicação 1995-03-01
Publicado em Diabetes Research and Clinical Practice. Clare: Elsevier Sci Publ Ireland Ltd, v. 27, n. 3, p. 205-210, 1995.
ISSN 0168-8227 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 205-210
Fonte http://dx.doi.org/10.1016/0168-8227(95)01047-H
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995RL00200008
Endereço permanente http://repositorio.unifesp.br/handle/11600/25472

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta