THE PILOCARPINE MODEL of EPILEPSY

THE PILOCARPINE MODEL of EPILEPSY

Autor Cavalheiro, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioural and electrographic changes that can be divided in three distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behaviour which varies fi-om 4 to 44 days,,and (c) a chronic period with spontaneous recurrent seizures (SRSs). the main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal, Therefore, this novel and unique experimental approach may serve as a model of epilepsy mimicking the human condition.
Palavra-chave PILOCARPINE
STATUS EPILEPTICUS
LIMBIC EPILEPSY, RATS
Idioma Inglês
Data de publicação 1995-02-01
Publicado em Italian Journal of Neurological Sciences. Milan: Masson Divisione Periodici, v. 16, n. 1-2, p. 33-37, 1995.
ISSN 0392-0461 (Sherpa/Romeo, fator de impacto)
Publicador Masson Divisione Periodici
Extensão 33-37
Fonte http://dx.doi.org/10.1007/BF02229072
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995RD03500005
Endereço permanente http://repositorio.unifesp.br/handle/11600/25458

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