A RANDOMIZED BLINDED COMPARISON of 2 DOSES of ANTIVENOM in the TREATMENT of BOTHROPS ENVENOMING in SAO-PAULO, BRAZIL

A RANDOMIZED BLINDED COMPARISON of 2 DOSES of ANTIVENOM in the TREATMENT of BOTHROPS ENVENOMING in SAO-PAULO, BRAZIL

Autor Jorge, M. T. Google Scholar
Cardoso, JLC Google Scholar
Castro, SCB Google Scholar
Ribeiro, L. Google Scholar
Franca, FOS Google Scholar
Dealmeida, MES Google Scholar
Kamiguti, A. S. Google Scholar
Santomartins, I. S. Google Scholar
Santoro, M. L. Google Scholar
Mancau, JEC Google Scholar
Warrell, D. A. Google Scholar
Theakston, RDG Google Scholar
Instituição UNIV LIVERPOOL LIVERPOOL SCH TROP MED
Universidade Federal de Uberlândia (UFU)
INST BUTANTAN
UNIV LIVERPOOL
Universidade Federal de São Paulo (UNIFESP)
UNIV OXFORD
Resumo An earlier study in São Paulo state suggested that the dose for patients with mild or moderate envenoming by Bothrops snakes (mainly Bothrops jararaca) could be effectively decreased to 4 ampoules (40 mL) of Brazilian Bothrops polyspecific antivenom. the present 'blinded' study examined the lowest dose studied in the first trial (equivalent to 4 x 10 mL ampoules) and half that dose of antivenom (equivalent to 2 x 10 mL ampoules) in 2 similar groups of 170 patients who were comparable in all respects before treatment. the majority of patients showed rapid clinical improvement after treatment with either dose regimen and rapid restoration of blood coagulability and cessation of bleeding. There was no apparent difference between the 2 groups of patients in any respect. the study confirmed that, in such patients, the dose of antivenom can be decreased from 4 ampoules to 2 ampoules without reduction of therapeutic efficacy and it is highly likely that this reduction will result in a decrease of early anaphylactic reactions caused by the antivenom.
Assunto SNAKE BITE
BOTHROPS
ANTIVENOM
BRAZIL
Idioma Inglês
Data 1995-01-01
Publicado em Transactions of the Royal Society of Tropical Medicine and Hygiene. London: Royal Soc Tropical Medicine, v. 89, n. 1, p. 111-114, 1995.
ISSN 0035-9203 (Sherpa/Romeo, fator de impacto)
Editor Royal Soc Tropical Medicine
Extensão 111-114
Fonte http://dx.doi.org/10.1016/0035-9203(95)90678-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1995QY30000031
URI http://repositorio.unifesp.br/handle/11600/25454

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