THE EFFECT of CORTICOSTERONE in RATS SUBMITTED TO the ELEVATED PLUS-MAZE and TO PENTYLENETETRAZOL-INDUCED CONVULSIONS

THE EFFECT of CORTICOSTERONE in RATS SUBMITTED TO the ELEVATED PLUS-MAZE and TO PENTYLENETETRAZOL-INDUCED CONVULSIONS

Autor Andreatini, R. Google Scholar
LEITE, JR Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo 1. in order to examine the effects of corticosterone in the anxiety response, the effect of acute, subchronic and chronic corticosterone (CORT) administration were studied using two animal models to study using two animal models to study anxiolytic effects of drugs: the elevated plus-maze and the blockade of pentylenetetrazol (PTZ)-induced clonic convulsion.2. the results obtained with the plus-maze showed an increase in the percentage of open arm entries and time spent in the open arms after acute treatment with the CORT. These results may be interpreted as an anxiolytic effect of corticosterone. Three days of vehicle treatment followed by an acute CORT administration, produced results that should also indicate anxiolytic effect of the corticosteroid. No effect was seen after 14 days of vehicle treatment followed by an acute CORT injection. Subchronic or chronic CORT treatment did not produce results different from controls. CORT treatment did not affect the PTZ-induced clonic convulsion.3. in conclusion these results suggest that the acute anxiolytic effect observed in the elevated plus-maze did not occur after repeated CORT administration or mild stressors. Moreover they also suggest that the anxiolytic effect did not involve GABA mechanisms.
Palavra-chave ANXIOLYTIC EFFECT
ANIMAL MODELS
CORTICOSTERONE
ELEVATED PLUS-MAZE
PENTYLENETETRAZOL-INDUCED CONVULSION
Idioma Inglês
Data de publicação 1994-12-01
Publicado em Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 18, n. 8, p. 1333-1347, 1994.
ISSN 0278-5846 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1333-1347
Fonte http://dx.doi.org/10.1016/0278-5846(94)90097-3
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:A1994PU84200009
Endereço permanente http://repositorio.unifesp.br/handle/11600/25451

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