LOSS of STRIATAL HIGH-AFFINITY NGF BINDING-SITES in PROGRESSIVE SUPRANUCLEAR PALSY BUT NOT in PARKINSONS-DISEASE

LOSS of STRIATAL HIGH-AFFINITY NGF BINDING-SITES in PROGRESSIVE SUPRANUCLEAR PALSY BUT NOT in PARKINSONS-DISEASE

Autor Villares, J. Google Scholar
Strada, O. Google Scholar
Faucheux, B. Google Scholar
Javoyagid, F. Google Scholar
Agid, Y. Google Scholar
Hirsch, E. C. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo I-125-Nerve growth factor (NGF) binding sites were analyzed by autoradiography in the striatum of 3 central subjects, 3 patients with Parkinson's disease and 3 patients with progressive supranuclear palsy. A high level of I-125-NGF binding was observed (0.3-0.4 fmol/mg of tissue equivalent) in the striatum and the nucleus basalis of Meynert of control patients. Pockets of lower I-125-NGF binding corresponding to acetylcholinesterase-poor striosomes were detected in the striatum of control subjects and patients with Parkinson's disease or progressive supranuclear palsy. When compared to controls, the density of I-125-NGF binding sites was reduced by 30% in the striatum of patients with progressive supranuclear palsy but not reduced in that of patients with Parkinson's disease. I-125-NGF binding was not significantly decreased in the nucleus basalis of Meynert in either diseases. Since NGF receptors are thought to be localized on cholinergic neurons in the striatum, the decrease in NGF binding is compatible with the loss of cholinergic neurons reported in the striatum from PSP patients.
Palavra-chave CHOLINERGIC NEURON
NERVE GROWTH FACTOR
PARKINSONS DISEASE
PROGRESSIVE SUPRANUCLEAR PALSY
AUTORADIOGRAPHY
Idioma Inglês
Data de publicação 1994-11-21
Publicado em Neuroscience Letters. Clare: Elsevier Sci Publ Ireland Ltd, v. 182, n. 1, p. 59-62, 1994.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 59-62
Fonte http://dx.doi.org/10.1016/0304-3940(94)90205-4
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994PY09300016
Endereço permanente http://repositorio.unifesp.br/handle/11600/25447

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