THE ROC CURVE in the EVALUATION of FASTING CAPILLARY BLOOD-GLUCOSE AS A SCREENING-TEST TOR DIABETES and IGT

THE ROC CURVE in the EVALUATION of FASTING CAPILLARY BLOOD-GLUCOSE AS A SCREENING-TEST TOR DIABETES and IGT

Autor Bortheiry, A. L. Google Scholar
Malerbi, D. A. Google Scholar
Franco, L. J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
UNIV RIO GRANDE
Resumo OBJECTIVE - To assess the performance of different cutoff points of fasting capillary glycemia (FCG) in the diagnosis of diabetes and impaired glucose tolerance (IGT) using the receiver operating characteristics (ROC) curve approach.RESEARCH DESIGN and METHODS- This study included a sample of 4,019 subjects without a previous history of diabetes who were recruited for a confirmatory 2-h post-glucose challenge capillary glycemia from a larger sample of 21,847 individuals screened with FCG. the sensitivity and the specificity of FCG as a screening test were analyzed in the cutoff range 3.9-8.9 mmol/l, and the corresponding ROC curves were plotted to assess the performance of the lest.RESULTS - the screening test performance was better for diabetes than for IGT in the full range of cutoff points studied. Sensitivities ranged between 37.9 and 97.1% for diabetes and 1.8 and 94.4% for IGT; the areas under the ROC curves were 0.91 +/- 0.01 and 0.75 +/- 0.01, respectively. the cutoffs showing the best equilibrium between sensitivity and specificity approached 5.6 and 5.0 mmol/l for diabetes and IGT, respectively. Factors such as age, color, and family history of diabetes can affect the screening test performance.CONCLUSIONS - ROC curves can provide useful information toward improving the usefulness of FCG as a screening test for abnormalities of glucose tolerance.
Idioma Inglês
Data de publicação 1994-11-01
Publicado em Diabetes Care. Alexandria: Amer Diabetes Assoc, v. 17, n. 11, p. 1269-1272, 1994.
ISSN 0149-5992 (Sherpa/Romeo, fator de impacto)
Publicador Amer Diabetes Assoc
Extensão 1269-1272
Fonte http://dx.doi.org/10.2337/diacare.17.11.1269
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994PN84300005
Endereço permanente http://repositorio.unifesp.br/handle/11600/25445

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