SICKLE-CELL DISEASE in A BRAZILIAN POPULATION FROM SAO-PAULO - A STUDY of the BETA(S) HAPLOTYPES

SICKLE-CELL DISEASE in A BRAZILIAN POPULATION FROM SAO-PAULO - A STUDY of the BETA(S) HAPLOTYPES

Autor Goncalves, M. S. Google Scholar
Nechtman, J. F. Google Scholar
Figueirerdo, M. S. Google Scholar
Kerbauy, J. Google Scholar
Arruda, V. R. Google Scholar
Sonati, M. F. Google Scholar
Saad, SOT Google Scholar
Costa, F. F. Google Scholar
Stoming, T. A. Google Scholar
Instituição MED COLL GEORGIA
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Resumo In this study we have determined the frequency of beta(s) haplotypes in a Brazilian sickle cell disease population from São Paulo, Brazil, by analyzing sequence variations in the immediate 5' flanking and second intervening sequence (IVSII) regions of the gamma globin genes. This association between sequence differences and beta(s) haplotype backgrounds was determined by screening genomic DNA samples using dot blot analysis of polymerase chain reaction products. We studied 148 beta(s) chromosomes, and found that haplotype 20 (CAR or Bantu) signif icantly predominated in this population. This is in agreement with the findings of the historical Portuguese Atlantic slave
Palavra-chave B-S HAPLOTYPES
(G)GAMMA GLOBIN GENE
BRAZIL
Idioma Inglês
Data de publicação 1994-11-01
Publicado em Human Heredity. Basel: Karger, v. 44, n. 6, p. 322-327, 1994.
ISSN 0001-5652 (Sherpa/Romeo, fator de impacto)
Publicador Karger
Extensão 322-327
Fonte http://dx.doi.org/10.1159/000154238
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994PU52000005
Endereço permanente http://repositorio.unifesp.br/handle/11600/25444

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