EFFECT of DIFFERENT GLYCOSAMINOGLYCANS in A GUINEA-PIG CAROTID-ARTERY THROMBOSIS MODEL

EFFECT of DIFFERENT GLYCOSAMINOGLYCANS in A GUINEA-PIG CAROTID-ARTERY THROMBOSIS MODEL

Autor Mattar, L. Google Scholar
Maffei, FHA Google Scholar
Nader, H. B. Google Scholar
Dietrich, C. P. Google Scholar
Curi, P. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Heparin is the most frequently used drug for the prevention and treatment of thrombosis. Its use, however, is restricted by its side-effects. To study the efficacy of other glycosaminoglycans that could substitute heparin in the management of arterial thrombosis, 60 guinea-pigs were randomly allocated into 6 groups: G1= control, G2= heparin (150 IU/kg), G3= heparan sulfate from beef pancreas (2.5 mg/kg), G4= heparan sulfate from beef lung (2.5 mg/kg), G5= N-acetylated heparan from beef pancreas, G6= dermatan sulfate from beef intestine (2.5 mg/kg). Ten minutes after intravenous injection of the drugs, thrombosis was induced by the injection of a 50% glucose solution into a segment of the right carotid artery isolated between 2 thread loops during 10 minutes. Three hours later the artery was re-exposed and if a thrombus was present it was measured, withdrawn and weighed. Thrombin time and activated partial thromboplastin time were measured in all animals. Thrombus developed in 90% of the animals in the control group, 0% in G2 and G3, 62.5% in G4, 87.5% in G5 and G6. Only in the animals treated with heparin the coagulation tests were prolonged. in conclusion, in the used dose only the heparan sulfate from beef pancreas presented an antithrombotic effect similar to heparin in this experimental model.
Palavra-chave EXPERIMENTAL THROMBOSIS
GLYCOSAMINOGLYCANS
ARTERIAL THROMBOSIS
HEPARIN
HEPARAN SULFATE
DERMATAN SULFATE
Idioma Inglês
Data de publicação 1994-09-15
Publicado em Thrombosis Research. Oxford: Pergamon-Elsevier B.V., v. 75, n. 6, p. 591-599, 1994.
ISSN 0049-3848 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 591-599
Fonte http://dx.doi.org/10.1016/0049-3848(94)90171-6
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994PF86000002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25433

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