Apparently normal frequency of congenital anomalies in the highly polluted town of Cubatão, Brazil

Apparently normal frequency of congenital anomalies in the highly polluted town of Cubatão, Brazil

Autor Monteleone-Neto, Roque Autor UNIFESP Google Scholar
Castilla, Eduardo Enrique Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
INST OSWALDO CRUZ
CEMIC
Resumo Anencephaly is Suspected to cluster in the municipality of Cubatao (Brazil), and is attributed to industrial pollution. We surveyed malformations prospectively in 10,000 births, in 3 consecutive series, corresponding to 3 maternity hospital in Cubatao, under working definitions and norms taken from the ECLAMC (Latin American Collaborative Study of Congenital Malformations). the sample from Cubatao had a higher proportion of black racial ancestry, and lower frequencies for stillbirths and for immediate neonatal death, than in the rest of South America.The birth prevalence of malformations varied between the 3 hospitals in Cubatao, due to differences in ascertainment of minor defects. A higher-than-expected prevalence rate in Cubatao was observed only for postaxial polydactyly, probably due to a higher proportion of black racial ancestry, while lower-than-expected rates were obtained for congenital dislocation of the hip, and for babies with multiple congenital anomalies patterns, both of them attributed to underascertainment of minor defects.These observations do not support the suspicion of an elevated birth prevalence rate for anencephaly, neural tube defects, or any other major congenital malformation in Cubatao. (C) 1994 Wiley-Liss, Inc.
Palavra-chave MALFORMATIONS
ANENCEPHALY
CUBATAO
Idioma Inglês
Data de publicação 1994-09-01
Publicado em American Journal of Medical Genetics. New York: Wiley-liss, v. 52, n. 3, p. 319-323, 1994.
ISSN 0148-7299 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 319-323
Fonte http://dx.doi.org/10.1002/ajmg.1320520313
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994PE21400012
Endereço permanente http://repositorio.unifesp.br/handle/11600/25427

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