EFFECT of VALEPOTRIATES ON the BEHAVIOR of RATS in the ELEVATED PLUS-MAZE DURING DIAZEPAM WITHDRAWAL

EFFECT of VALEPOTRIATES ON the BEHAVIOR of RATS in the ELEVATED PLUS-MAZE DURING DIAZEPAM WITHDRAWAL

Autor Andreatini, R. Google Scholar
LEITE, JR Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The effect of a mixture of valepotriates on the elevated plus-maze performance of diazepam withdrawn rats was evaluated. the rats were chronically (28 days) treated with diazepam (doses increased up to 5.0 mg/kg) and then treated with control solution for 3 days to induce a withdrawal syndrome. Chronically vehicle-treated rats were used as control. the abstinent animals treated with vehicle showed a significant decrease in the percentage of time spent in the open arms when compared with the control animals. Diazepam and valerian 12.0 mg/kg reversed this anxiogenic effect. Valerian 6.0 mg/kg did not show any difference in relation to the others group.
Palavra-chave ANIMAL MODEL
ANXIETY
BENZODIAZEPINE WITHDRAWAL
ELEVATED PLUS-MAZE
VALEPOTRIATE
Idioma Inglês
Data de publicação 1994-08-01
Publicado em European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 260, n. 2-3, p. 233-235, 1994.
ISSN 0014-2999 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 233-235
Fonte http://dx.doi.org/10.1016/0014-2999(94)90342-5
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994PA77900017
Endereço permanente http://repositorio.unifesp.br/handle/11600/25423

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