TESTOSTERONE CONTROL of END-PLATE and NON-END-PLATE ACETYLCHOLINESTERASE in the RAT LEVATOR ANI MUSCLE

TESTOSTERONE CONTROL of END-PLATE and NON-END-PLATE ACETYLCHOLINESTERASE in the RAT LEVATOR ANI MUSCLE

Autor Godinho, R. O. Google Scholar
Souccar, C. Google Scholar
Lapa, A. J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The time course of effects of castration (5-60 days) and testosterone treatment (15-60 days) of adult male rats were examined on the endplate (+EP) and non-endplate (-EP) acetylcholinesterase (AChE) of the androgen-dependent levator ani (LA) muscle. the thiocholine method was used to determine the enzyme activity. Castration caused LA muscle atrophy within 5 days but reduced the -EP and +EP AChE after 10 and 20 days, respectively. Following 30 days castration -EP and +EP AChE reached respectively 41% and 35% of control activity. Testosterone retrieval restored the control values of both muscle weight and total AChE after 15 and 60 days, respectively. Recovery of the +EP AChE preceded that of -EP AChE by 30 days. the results showed that in the rat LA muscle, +EP and -EP AChE depend on a continuous testosterone regulation that predominates at +EP region spreading thereafter to -EP region. Those data suggest a hormone regulation of AChE exerted indirectly through the synthesis and release of neurotrophic substances.
Palavra-chave ACETYLCHOLINESTERASE
LEVATOR ANI MUSCLE
TESTOSTERONE
SKELETAL MUSCLE
NEUROMUSCULAR JUNCTION
Idioma Inglês
Data de publicação 1994-06-01
Publicado em Neurochemical Research. New York: Plenum Publ Corp, v. 19, n. 6, p. 657-663, 1994.
ISSN 0364-3190 (Sherpa/Romeo, fator de impacto)
Publicador Plenum Publ Corp
Extensão 657-663
Fonte http://dx.doi.org/10.1007/BF00967703
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994NK71000003
Endereço permanente http://repositorio.unifesp.br/handle/11600/25411

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