A CONTROLLED TRIAL of PULSE CYCLOPHOSPHAMIDE VERSUS PULSE METHYLPREDNISOLONE in SEVERE LUPUS NEPHRITIS

A CONTROLLED TRIAL of PULSE CYCLOPHOSPHAMIDE VERSUS PULSE METHYLPREDNISOLONE in SEVERE LUPUS NEPHRITIS

Autor Sesso, R. Google Scholar
Monteiro, M. Google Scholar
Sato, E. Google Scholar
Kirsztajn, G. Google Scholar
Silva, L. Google Scholar
Ajzen, H. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo We carried out a prospective randomized trial comparing pulse cyclophosphamide and pulse methylprednisolone in 29 patients with severe lupus nephritis in activity. Patients were assigned to one of two regimens: monthly pulse cyclophosphamide (0.5-1.0 g/m2 body surface area) for 4 months, followed by bimonthly doses for 4 months and quarterly doses for 6 months (14 patients) or pulse methylprednisolone (10-20 mg/kg weight) initially for 3 consecutive days and thereafter in the same intervals as the alternative regimen (15 patients). the mean follow-up was 15 months. Two patients in the cyclophosphamide group and three in the methylprednisolone group died. Renal failure (doubling of serum creatinine) developed in four patients in the cyclophosphamide group compared with five patients in the methylprednisolone group. Cumulative probability of not doubling serum creatinine was similar for cyclophosphamide and methylprednisolone groups (0.66 vs 0.69, respectively, P > 0.20, after 18 months). Cumulative probability of survival without renal failure was also not significantly different (0.61 and 0.63, respectively, P > 0.20, after 18 months). These results suggest that pulse cyclophosphamide is as effective as pulse methylprednisolone in preserving renal function in patients with severe lupus nephritis.
Palavra-chave SYSTEMIC
LUPUS
ERYTHEMATOSUS
NEPHRITIS
CYCLOPHOSPHAMIDE
METHYLPREDNISOLONE
PULSE
TREATMENT
Idioma Inglês
Data de publicação 1994-04-01
Publicado em Lupus. Basingstoke: Stockton Press, v. 3, n. 2, p. 107-112, 1994.
ISSN 0961-2033 (Sherpa/Romeo, fator de impacto)
Publicador Stockton Press
Extensão 107-112
Fonte http://dx.doi.org/10.1177/096120339400300209
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994NU18700009
Endereço permanente http://repositorio.unifesp.br/handle/11600/25402

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