METABOLIC CHANGES in LYMPHOID ORGANS AS INDUCED BY FATTY ACIDS-RICH DIETS DURING AGING

METABOLIC CHANGES in LYMPHOID ORGANS AS INDUCED BY FATTY ACIDS-RICH DIETS DURING AGING

Autor Guimaraes, ARP Google Scholar
Sitnik, R. H. Google Scholar
Curi, CMON Google Scholar
Curi, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
UNIV ESTADUAL CEARA
Resumo Previous reports of our laboratory have shown that w-6 PUFA-rich diets (UC) given to rats during 6 weeks causes important changes of the metabolism of the lymphoid organs. in this study, the effect of saturated fatty acids-rich diet (SC) and also the persistence of the changes caused by (UC) were investigated during ageing (14 months). the major changes previously reported for UC fed rats, during 6 weeks, fully persisted when this feeding condition was maintained for 14 months. Moreover, the SC group also showed modifications of the activities of key enzymes of glucose and glutamine metabolism of the lymphoid organs with ageing. Both groups fed fatty acids-rich diets markedly reduced the rate of lipogenesis in the liver, spleen, and thymus in contrast to slight changes reported for 6 weeks. These results suggest that fatty acids-rich diets, by causing important metabolic alterations, may pronounce the impairment of the immune function observed during ageing.
Palavra-chave POLYUNSATURATED FATTY ACIDS
SATURATED FATTY ACIDS
METABOLISM
IMMUNE TISSUES
AGING
Idioma Inglês
Data de publicação 1994-04-01
Publicado em Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 55, n. 4, p. 691-697, 1994.
ISSN 0031-9384 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 691-697
Fonte http://dx.doi.org/10.1016/0031-9384(94)90046-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994NA80000014
Endereço permanente http://repositorio.unifesp.br/handle/11600/25394

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