EFFECTS of A PROLONGED ADMINISTRATION of VALEPOTRIATES in RATS ON the MOTHERS and THEIR OFFSPRING

EFFECTS of A PROLONGED ADMINISTRATION of VALEPOTRIATES in RATS ON the MOTHERS and THEIR OFFSPRING

Autor Tufik, S. Google Scholar
Fujita, K. Google Scholar
Seabra, MDV Google Scholar
Lobo, L. L. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Valeriana officinalis L. (Valerianaceae) is widely known to be associated with sedative properties. the effects of a valepotriates mixture on mothers and progeny were evaluated in rats. A 30-day administration of valepotriates did not change the average length of estral cycle, nor the number of estrous phases during this period. Also, there were no changes on the fertility index. Fetotoxicity and external examination studies did not show differences, although internal examination revealed an increase in number of retarded ossification after the highest doses employed - 12 and 24 mg/kg. No changes were detected in the development of the offspring after treatment during pregnancy. As for temperature, valepotriates caused a hypothermizant effect after administration by the intraperitoneal route but not after oral administration. Generally, the valepotriates employed induced some alterations after administration by the intraperitoneal route, but doses given orally were inocuous to pregnant rats and their offspring.
Palavra-chave FERTILITY
FETOTOXICITY
PROGENY
RATS
VALEPOTRIATES
Idioma Inglês
Data de publicação 1994-01-01
Publicado em Journal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 41, n. 1-2, p. 39-44, 1994.
ISSN 0378-8741 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 39-44
Fonte http://dx.doi.org/10.1016/0378-8741(94)90055-8
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994MX06600005
Endereço permanente http://repositorio.unifesp.br/handle/11600/25377

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