EVIDENCE for PARTICIPATION of NITRIC-OXIDE in EXCITATORY NEUROTRANSMISSION in RAT VAS-DEFERENS

EVIDENCE for PARTICIPATION of NITRIC-OXIDE in EXCITATORY NEUROTRANSMISSION in RAT VAS-DEFERENS

Autor VLADIMIROVA, I Google Scholar
Jurkiewicz, N. H. Google Scholar
Jurkiewicz, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo A depression of the fast, non-adrenergic, and also of the slow, adrenergic, components of muscle contraction in response to intramural nerve stimulation was induced by the blocker of nitric oxide synthase N-G-nitro-L-arginine methyl ester (L-NAME), in rat vas deferens. Effects of exogenous noradrenaline or ATP were not reduced by L-NAME, However, L-arginine also caused an inhibition of electrically induced effects in most of the preparations, contrary to the expectations for a precursor of nitric oxide synthesis. in spite of these difficulties L-arginine antagonized the action of L-NAME. These results indicate that nitric oxide is involved in excitatory nerve-muscle transmission in vas deferens.
Palavra-chave NEUROTRANSMISSION
RAT VAS DEFERENS
NITRIC OXIDE
L-NAME
L-ARGININE
Idioma Inglês
Data de publicação 1994-01-01
Publicado em Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 55, n. 14, p. 1123-1128, 1994.
ISSN 0024-3205 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1123-1128
Fonte http://dx.doi.org/10.1016/0024-3205(94)00240-1
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994PE17600004
Endereço permanente http://repositorio.unifesp.br/handle/11600/25374

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