A common motif in G-protein-coupled seven transmembrane helix receptors

A common motif in G-protein-coupled seven transmembrane helix receptors

Autor Oliveira, Laerte Autor UNIFESP Google Scholar
Paiva, Antonio Cechelli de Mattos Autor UNIFESP Google Scholar
Vriend, Gerrit Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
EMBL
Resumo G-protein-coupled receptors all share the seven transmembrane helix motif similar to bacteriorhodopsin. This similarity was exploited to build models for these receptors. From an analysis of a multi-sequence alignment of 225 G-protein-coupled receptors belonging to the rhodopsin-like superfamily, conclusions could be drawn about functional residues. Seven residues in the transmembrane regions are conserved throughout all aligned receptors. These residues cluster at the cytosolic side of the transmembrane helices and are for all rhodopsin-like G-protein-coupled receptors implied in signal transduction. An analysis of correlated mutations reveals a number of residues, both in the helices and in the cytosolic loops, that might be important in the signal transduction pathway in subfamilies of this receptor family.
Palavra-chave G-PROTEIN-COUPLED RECEPTORS
MODELING
Idioma Inglês
Data de publicação 1993-12-01
Publicado em Journal of Computer-aided Molecular Design. Leiden: Escom Sci Publ Bv, v. 7, n. 6, p. 649-658, 1993.
ISSN 0920-654X (Sherpa/Romeo, fator de impacto)
Publicador Escom Sci Publ Bv
Extensão 649-658
Fonte http://dx.doi.org/10.1007/BF00125323
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1993MU48100002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25367

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