IN-VITRO ACTIVITY of 3 CARBAPENEM ANTIBIOTICS - COMPARATIVE-STUDIES WITH BIAPENEM (L-627), IMIPENEM, and MEROPENEM AGAINST AEROBIC PATHOGENS ISOLATED WORLDWIDE

IN-VITRO ACTIVITY of 3 CARBAPENEM ANTIBIOTICS - COMPARATIVE-STUDIES WITH BIAPENEM (L-627), IMIPENEM, and MEROPENEM AGAINST AEROBIC PATHOGENS ISOLATED WORLDWIDE

Autor Hoban, D. J. Google Scholar
Jones, R. N. Google Scholar
Yamane, N. Google Scholar
Frei, R. Google Scholar
Trilla, A. Google Scholar
Pignatari, A. C. Google Scholar
Instituição UNIV IOWA
KUMAMOTO UNIV
KANTONSSPITAL BASEL
UNIV BARCELONA
Universidade Federal de São Paulo (UNIFESP)
Resumo The in vitro activity of biapenem (formerly L-627 or LJC10, 627), a new carbapenem, was compared with that of imipenem and meropenem against >6000 clinically significant pathogens isolated in six countries worldwide. Biapenem was active against members of the family Enterobacteriaceae with a 90% minimum inhibitory concentration (MIC(90)) ranging from less than or equal to 0.06 to 2 mu g/ml. Only Serratia spp. and Providencia spp. were less susceptible (MIC(90), 8 mu g/ml). Pseudomonas aeruginosa and Xanthomonas maltophilia displayed an MIC(90) of greater than or equal to 8 mu g/ml biapenem/ml whereas Acinetobacter spp. were susceptible at less than or equal to 1 mu g/ml. Oxacillin-resistant staphylococci were resistant to biapenem at >8 mu g/ml whereas oxacillin-sensitive staphylococci were susceptible at less than or equal to 1 mu g/ml. Biapenem, imipenem, and meropenem displayed poor activity against Ent. faecium (MIC(90), greater than or equal to 8 mu g/ml), and only imipenem displayed slightly better activity against Ent. faecalis (MIC(90), 4 mu g/ml). the rank order of activity against groups of isolates was Enterobacteriaceae (meropenem>biapenem greater than or equal to imipenem), Ps. aeruginosa (biapenem=meropenem=imipenem), oxacillin-sensitive staphylococci (imipenem greater than or equal to biapenem=merepenem), oxacillin-resistant staphylococci (biapenem=meropenem=imipenem), and Enterococcus spp. (biapenem=meropenem=imipenem). These in vitro results suggest that further developmental work on biapenem is warranted.
Idioma Inglês
Data de publicação 1993-11-01
Publicado em Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 17, n. 4, p. 299-305, 1993.
ISSN 0732-8893 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 299-305
Fonte http://dx.doi.org/10.1016/0732-8893(93)90039-A
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1993MQ26300007
Endereço permanente http://repositorio.unifesp.br/handle/11600/25361

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