STRUCTURE of HEPARAN-SULFATE FROM the FRESH-WATER MOLLUSK ANOMANTIDAE SP - SEQUENCING of ITS DISACCHARIDE UNITS

STRUCTURE of HEPARAN-SULFATE FROM the FRESH-WATER MOLLUSK ANOMANTIDAE SP - SEQUENCING of ITS DISACCHARIDE UNITS

Autor Ferreira, TMPC Google Scholar
Medeiros, MGL Google Scholar
Dietrich, C. P. Google Scholar
Nader, H. B. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UNIV FED RIO GRANDE NORTE
Resumo 1. the disaccharide sequences of a heparan sulfate isolated from Anomantidae sp. was determined with the aid of heparitinase I, heparitinase II from Flavobacterium heparinum, mollusc beta-glucuronidase and alpha-N-acetylglucosaminidase besides nitrous acid degradation and chemical analyses.2. Like the mammalian heparan sulfates the mollusc heparan sulfate is composed of different oligosaccharide blocks of N-acetylated disaccharides, N-sulfated disaccharides and N,6-sulfated disaccharides and has in its nonreducing end the monosaccharide glucosamine 2,6-disulfate.3. the oligosaccharides produced by heparitinase I degradation contain at their reducing ends a N-acetylated, 6-sulfated disaccharide.4. These and other results lead to the conclusion that the general structure of the heparan sulfate is maintained through evolution.
Idioma Inglês
Data de publicação 1993-09-01
Publicado em International Journal of Biochemistry. Oxford: Pergamon-Elsevier B.V., v. 25, n. 9, p. 1219-1225, 1993.
ISSN 0020-711X (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1219-1225
Fonte http://dx.doi.org/10.1016/0020-711X(93)90070-U
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1993LW31200001
Endereço permanente http://repositorio.unifesp.br/handle/11600/25350

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