PLASMA KALLIKREIN and THROMBIN ARE CLEARED THROUGH UNRELATED HEPATIC PATHWAYS

PLASMA KALLIKREIN and THROMBIN ARE CLEARED THROUGH UNRELATED HEPATIC PATHWAYS

Author Loureirosilva, M. R. Google Scholar
Kouyoumdjian, M. Google Scholar
Borges, D. R. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Plasma kallikrein (PK) and thrombin (TH), serine proteinases formed from inactive precursors, participate in important body defence mechanisms. the isolated hepatocyte recognizes TH, and the liver clears PK by calcium-independent receptors through mechanisms that are not yet clearly understood. It is known that heparin impairs the binding of TH to isolated liver cells through the inhibition of high affinity receptors. Using an isolated, exsanguinated and perfused rat liver preparation we confirmed that the TH hepatic clearance is calcium-independent and affected by heparin; PK clearance rates both in the presence (t1/2 10 +/- 2 min) or the absence (t1/2 10 +/- 1 min) of heparin were similar; the presence of beta-galactosides does not impair the TH clearance but adversely affects the PK clearance and a large excess of TH does not impair the PK clearance rate (t1/2 6 +/- 1 min). These results indicate that PK and TH are cleared by calcium-independent but otherwise unrelated hepatic pathways and suggest that TH may indeed facilitate the PK clearance by the liver.
Keywords KALLIKREIN
THROMBIN
LIVER
ENDOCYTOSIS
Language English
Date 1993-08-01
Published in Blood Coagulation & Fibrinolysis. London: Rapid Science Publishers, v. 4, n. 4, p. 551-554, 1993.
ISSN 0957-5235 (Sherpa/Romeo, impact factor)
Publisher Rapid Science Publishers
Extent 551-554
Origin http://dx.doi.org/10.1097/00001721-199308000-00004
Access rights Closed access
Type Article
Web of Science ID WOS:A1993LR29300004
URI http://repositorio.unifesp.br/handle/11600/25346

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