PLASMA KALLIKREIN and THROMBIN ARE CLEARED THROUGH UNRELATED HEPATIC PATHWAYS

PLASMA KALLIKREIN and THROMBIN ARE CLEARED THROUGH UNRELATED HEPATIC PATHWAYS

Autor Loureirosilva, M. R. Google Scholar
Kouyoumdjian, M. Google Scholar
Borges, D. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Plasma kallikrein (PK) and thrombin (TH), serine proteinases formed from inactive precursors, participate in important body defence mechanisms. the isolated hepatocyte recognizes TH, and the liver clears PK by calcium-independent receptors through mechanisms that are not yet clearly understood. It is known that heparin impairs the binding of TH to isolated liver cells through the inhibition of high affinity receptors. Using an isolated, exsanguinated and perfused rat liver preparation we confirmed that the TH hepatic clearance is calcium-independent and affected by heparin; PK clearance rates both in the presence (t1/2 10 +/- 2 min) or the absence (t1/2 10 +/- 1 min) of heparin were similar; the presence of beta-galactosides does not impair the TH clearance but adversely affects the PK clearance and a large excess of TH does not impair the PK clearance rate (t1/2 6 +/- 1 min). These results indicate that PK and TH are cleared by calcium-independent but otherwise unrelated hepatic pathways and suggest that TH may indeed facilitate the PK clearance by the liver.
Palavra-chave KALLIKREIN
THROMBIN
LIVER
ENDOCYTOSIS
Idioma Inglês
Data de publicação 1993-08-01
Publicado em Blood Coagulation & Fibrinolysis. London: Rapid Science Publishers, v. 4, n. 4, p. 551-554, 1993.
ISSN 0957-5235 (Sherpa/Romeo, fator de impacto)
Publicador Rapid Science Publishers
Extensão 551-554
Fonte http://dx.doi.org/10.1097/00001721-199308000-00004
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1993LR29300004
Endereço permanente http://repositorio.unifesp.br/handle/11600/25346

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