CARDIOVASCULAR EFFECTS PRODUCED BY MICROINJECTION of ANGIOTENSIN-(1-7) ON VASOPRESSOR and VASODEPRESSOR SITES of the VENTROLATERAL MEDULLA

CARDIOVASCULAR EFFECTS PRODUCED BY MICROINJECTION of ANGIOTENSIN-(1-7) ON VASOPRESSOR and VASODEPRESSOR SITES of the VENTROLATERAL MEDULLA

Autor Silva, LCS Google Scholar
Fontes, MAP Google Scholar
Campagnolesantos, M. J. Google Scholar
Khosla, M. C. Google Scholar
Campos, R. R. Google Scholar
Guertzenstein, P. G. Google Scholar
Santos, RAS Google Scholar
Instituição Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
CLEVELAND CLIN EDUC FDN
Resumo In this study, we determined the cardiovascular effects produced by micro-injection of the heptapeptide Angiotensin-(1-7) [Ang-(1-7)] into the rat ventrolateral medulla (VLM). Micro-injection of Ang-(1-7) into the rostral VLM and the caudal pressor area of the VLM produced significant increases in arterial pressure, comparable to that observed with micro-injection of Ang II. the changes in arterial pressure were associated with more variable changes in heart rate (HR) (usually tachycardia). On the other hand, micro-injection of Ang-(1-7) into the caudal depressor area induced decreases in arterial pressure and HR. the results suggest that, besides Ang II, Ang-(1-7) is involved in the mediation of the cardiovascular actions of the renin-angiotensin system in the VLM.
Palavra-chave VENTROLATERAL MEDULLA
ANGIOTENSIN-II
ANGIOTENSIN-(1-7)
VASOMOTOR ACTIVITY
Idioma Inglês
Data de publicação 1993-06-11
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 613, n. 2, p. 321-325, 1993.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 321-325
Fonte http://dx.doi.org/10.1016/0006-8993(93)90920-I
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1993LH29300023
Endereço permanente http://repositorio.unifesp.br/handle/11600/25334

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