EFFECT of FATTY ACID-RICH DIETS ON THYMOCYTE PROLIFERATION and THYMUS INVOLUTION DURING GROWING

EFFECT of FATTY ACID-RICH DIETS ON THYMOCYTE PROLIFERATION and THYMUS INVOLUTION DURING GROWING

Autor Egami, Mizue Imoto Autor UNIFESP Google Scholar
Guimaraes, ARP Google Scholar
Curi, CMPON Google Scholar
Curi, R. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The effect of polyunsaturated and saturated fatty acid-rich diet on the proliferation response of T and B lymphocytes in vitro was investigated. Also, a mitotic index of thymocytes and of thymus epithelial reticular-like cells and thymic involution coefficient were examined in vivo. w-6 PUFA-rich diet enhanced the rate of T (eightfold) and B (fourfold) lymphocyte proliferation, whereas saturated fatty acids did not show an important effect. However, both fat-rich diets increased the mitotic index of thymocytes and thymus involution index in vivo. These findings suggest that fat-rich diets may accelerate thymus involution during growing, possibly aggravating the impairment of the immune function which usually occurs under this condition.
Palavra-chave IMMUNE FUNCTION
GROWING
DIETARY FAT
THYMOCYTE PROLIFERATION
THYMUS INVOLUTION
Idioma Inglês
Data de publicação 1993-03-01
Publicado em Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 53, n. 3, p. 531-534, 1993.
ISSN 0031-9384 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 531-534
Fonte http://dx.doi.org/10.1016/0031-9384(93)90149-A
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1993KQ41100017
Endereço permanente http://repositorio.unifesp.br/handle/11600/25311

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