ADDITIVE EFFECTS of EXPOSURE TO SILICA DUST and SMOKING ON PULMONARY EPITHELIAL PERMEABILITY - A RADIOAEROSOL STUDY WITH TC-99M LABELED DTPA

ADDITIVE EFFECTS of EXPOSURE TO SILICA DUST and SMOKING ON PULMONARY EPITHELIAL PERMEABILITY - A RADIOAEROSOL STUDY WITH TC-99M LABELED DTPA

Autor Nery, L. E. Autor UNIFESP Google Scholar
Florencio, R. T. Autor UNIFESP Google Scholar
Sandoval, PRM Autor UNIFESP Google Scholar
Rodrigues, R. T. Autor UNIFESP Google Scholar
Alonso, G. Autor UNIFESP Google Scholar
Mason, G. R. Google Scholar
Instituição UCLA
Universidade Federal de São Paulo (UNIFESP)
Resumo Background Increased pulmonary epithelial permeability evaluated by the rate of clearance from lung to blood of the radioaerosol solute technetium-99m labelled diethylenetriamine pentacetate (Tc-99m-DTPA) has been reported in smokers and in workers exposed to silica dust. A study was carried out to determine whether there are additive effects of cigarette smoke and exposure to silica dust on clearance rates of Tc-99m-DTPA in ceramic workers.Methods Thirty one subjects with silicosis were studied, of whom 18 smoked cigarettes and 13 were non-smokers. They had similar histories of exposure to silica dust, and radiological alterations consistent with silicosis. the results from these patients were compared with those from normal subjects and smokers previously studied by the authors.Results Pulmonary function values were normal in most patients and not significantly different among groups. the median (range) rate of clearance of Tc-99m-DTPA in smokers with silicosis was 4.1 (1.9-22.7) %/minute, which was higher than the rates in non-smoking patients with silicosis of 2.2 (1.1-6.6) %/minute and in smokers without exposure to silica dust of 2.9 (1.6-4.5) %/minute. These differences were more evident and significant when the clearance rates of the lower lobes of the three groups were compared. Clearance rates higher than 3%/minute were much more frequent in smokers with silicosis (85%) than in non-smoking patients with silicosis (15%) and in smokers (40%).Conclusion in ceramic workers with radiographic changes resulting from exposure to silica dust, there is an additive effect of inhalation of silica dust and cigarette smoking on clearance rates of Tc-99m-DTPA.
Idioma Inglês
Data de publicação 1993-03-01
Publicado em Thorax. London: British Med Journal Publ Group, v. 48, n. 3, p. 264-268, 1993.
ISSN 0040-6376 (Sherpa/Romeo, fator de impacto)
Publicador British Med Journal Publ Group
Extensão 264-268
Fonte http://dx.doi.org/10.1136/thx.48.3.264
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1993KU68300017
Endereço permanente http://repositorio.unifesp.br/handle/11600/25309

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