METHODOLOGICAL CONSIDERATIONS in CASE-CONTROL STUDIES TO EVALUATE BCG VACCINE EFFECTIVENESS

METHODOLOGICAL CONSIDERATIONS in CASE-CONTROL STUDIES TO EVALUATE BCG VACCINE EFFECTIVENESS

Autor WUNSCHFILHO, V Google Scholar
Moncau, JEC Google Scholar
Nakao, N. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Several case-control studies evaluating the effectiveness of BCG vaccine in the last decade have presented contradictory results like previous prospective studies. Methodological differences could explain some of the case-control study results. This study explores the possibility that contradictory results could be imputed to the choice of different series of controls. Three controls were compared for each case of tuberculous meningitis: neighbourhood, hospital and household. BCG effectiveness estimates were 86.8%, 92.0% and 29.5%, respectively. the data indicated an interaction between BCG vaccine status and tuberculous focus. This could have influenced the lower effectiveness estimates found when cases were compared with household controls. the paper discusses aspects related to case-control studies applied to evaluate BCG effectiveness such as: incubation period and sufficient time since vaccination to allow development of an immune response; the presence of a tuberculous focus among the groups of cases and controls and the interaction between focus and BCG vaccination; recall bias; and optimum selection of controls in case-control studies in the context of infectious diseases.
Idioma Inglês
Data de publicação 1993-02-01
Publicado em International Journal of Epidemiology. Oxford: Oxford Univ Press United Kingdom, v. 22, n. 1, p. 149-155, 1993.
ISSN 0300-5771 (Sherpa/Romeo, fator de impacto)
Publicador Oxford Univ Press United Kingdom
Extensão 149-155
Fonte http://dx.doi.org/10.1093/ije/22.1.149
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1993KP20300021
Endereço permanente http://repositorio.unifesp.br/handle/11600/25305

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