OUTCOME of THYROID-FUNCTION in NEWBORNS FROM MOTHERS TREATED WITH AMIODARONE

OUTCOME of THYROID-FUNCTION in NEWBORNS FROM MOTHERS TREATED WITH AMIODARONE

Autor Matsumura, L. K. Google Scholar
Born, D. Google Scholar
Kunii, I. S. Google Scholar
Franco, D. B. Google Scholar
Maciel, RMB Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Amiodarone, a drug extensively used as an antiarrhythmic agent, contains 37% iodine and causes several thyroid abnormalities. the transplacental passage of amiodarone occurs with chronic therapy; we describe in this report the outcome of 9 pregnant women who used amiodarone (200 mg/day) for treatment of resistant tachycardia and the follow-up of their newborns. All women were clinically euthyroid at the 3rd trimester and showed expected values of thyroid hormones (mean +/- SD: total T4, 228 +/- 45 nmol/L; total T3, 4.0 +/- 0.65 nmol/L; TSH, 4.0 +/- 1.8 mU/L; negative thyroid antibodies). At birth all newborns were normal on routine examination with no goiter or corneal changes. T4 and TSH, measured on dried umbilical blood spots were normal or borderline-normal in 8 of 9 babies. Only 1 neonate presented clearly abnormal values of T4 and TSH (96 mU/L); on clinical grounds the baby was normal, without signs of hypothyroidism. At 1 month of life, T4 and TSH were normal. Follow-ups at 3, 6, and 12 months were normal We conclude that is not necessary to discontinue treatment with amiodarone in pregnant women with resistent tachycardia, but it is imperative to evaluate the thyroid function of the newborn, since transient hypothyroidism may occur.
Idioma Inglês
Data 1992-12-01
Publicado em Thyroid. Larchmont: Mary Ann Liebert Inc Publ, v. 2, n. 4, p. 279-281, 1992.
ISSN 1050-7256 (Sherpa/Romeo, fator de impacto)
Editor Mary Ann Liebert Inc Publ
Extensão 279-281
Fonte http://dx.doi.org/10.1089/thy.1992.2.279
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1992KK83300001
URI http://repositorio.unifesp.br/handle/11600/25289

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