GABAERGIC SYNAPTIC TRANSMISSION in PROJECTIONS FROM the BASAL FOREBRAIN and HIPPOCAMPAL-FORMATION TO the AMYGDALA - AN INVIVO IONTOPHORETIC STUDY

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dc.contributor.author Mello, LEAM
dc.contributor.author Tan, A. M.
dc.contributor.author Finch, D. M.
dc.date.accessioned 2016-01-24T11:40:09Z
dc.date.available 2016-01-24T11:40:09Z
dc.date.issued 1992-07-31
dc.identifier http://dx.doi.org/10.1016/0006-8993(92)91426-F
dc.identifier.citation Brain Research. Amsterdam: Elsevier B.V., v. 587, n. 1, p. 41-48, 1992.
dc.identifier.issn 0006-8993
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25268
dc.description.abstract We recorded extracellular responses from rat amygdaloid neurons in vivo after electrical stimulation of the basal forebrain and hippocampal formation. Iontophoretic application of the GABA(A) receptor antagonist, bicuculline, lead to the appearance of short latency evoked bursts after stimulation of either region. This occurred whether the baseline response was inhibitory or excitatory. Bicuculline only affected an early phase of inhibition, leaving a longer latency, longer duration phase unchanged or even increased. By contrast, the GABA(B) receptor antagonist, phaclofen, never produced such short latency evoked bursts. Both bicuculline and phaclofen increased the spontaneous rate of firing of amygdaloid neurons. the excitatory burst response to hippocampal formation stimulation of an amygdaloid candidate inhibitory neuron was blocked by CNQX (an antagonist of the AMPA subtype of glutamate receptor). Based on these and prior studies, it seems likely that the effects of hippocampal formation stimulation are mediated by feed-forward inhibition, in which GABAergic amygdaloid inhibitory neurons are excited by glutamatergic projections from the hippocampal formation. the effects of basal forebrain stimulation may be mediated by both feed-forward inhibition and direct, GABAergic inhibition. en
dc.format.extent 41-48
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Brain Research
dc.rights Acesso restrito
dc.subject LIMBIC SYSTEM en
dc.subject INHIBITORY NEURON en
dc.subject NEURAL NETWORK en
dc.subject DIAGONAL BAND en
dc.subject VENTRAL PALLIDUM en
dc.subject SUBSTANTIA INNOMINATA en
dc.subject SUBICULAR COMPLEX en
dc.subject ENTORHINAL CORTEX en
dc.subject SYNAPTIC POTENTIAL en
dc.subject GLUTAMATE en
dc.subject DENTATE GYRUS en
dc.title GABAERGIC SYNAPTIC TRANSMISSION in PROJECTIONS FROM the BASAL FOREBRAIN and HIPPOCAMPAL-FORMATION TO the AMYGDALA - AN INVIVO IONTOPHORETIC STUDY en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution UNIV CALIF LOS ANGELES
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation UNIV CALIF LOS ANGELES,BRAIN RES INST,73-364 CTR HLTH SCI,LOS ANGELES,CA 90024
dc.description.affiliation UNIV CALIF LOS ANGELES,REED NEUROL RES CTR,DEPT NEUROL,LOS ANGELES,CA 90024
dc.description.affiliation ESCOLA PAULISTA MED SCH,DEPT FISIOL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED SCH,DEPT FISIOL,BR-04023 São Paulo,BRAZIL
dc.identifier.doi 10.1016/0006-8993(92)91426-F
dc.description.source Web of Science
dc.identifier.wos WOS:A1992JK14000004



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