GABAERGIC SYNAPTIC TRANSMISSION in PROJECTIONS FROM the BASAL FOREBRAIN and HIPPOCAMPAL-FORMATION TO the AMYGDALA - AN INVIVO IONTOPHORETIC STUDY

GABAERGIC SYNAPTIC TRANSMISSION in PROJECTIONS FROM the BASAL FOREBRAIN and HIPPOCAMPAL-FORMATION TO the AMYGDALA - AN INVIVO IONTOPHORETIC STUDY

Autor Mello, LEAM Google Scholar
Tan, A. M. Google Scholar
Finch, D. M. Google Scholar
Instituição UNIV CALIF LOS ANGELES
Universidade Federal de São Paulo (UNIFESP)
Resumo We recorded extracellular responses from rat amygdaloid neurons in vivo after electrical stimulation of the basal forebrain and hippocampal formation. Iontophoretic application of the GABA(A) receptor antagonist, bicuculline, lead to the appearance of short latency evoked bursts after stimulation of either region. This occurred whether the baseline response was inhibitory or excitatory. Bicuculline only affected an early phase of inhibition, leaving a longer latency, longer duration phase unchanged or even increased. By contrast, the GABA(B) receptor antagonist, phaclofen, never produced such short latency evoked bursts. Both bicuculline and phaclofen increased the spontaneous rate of firing of amygdaloid neurons. the excitatory burst response to hippocampal formation stimulation of an amygdaloid candidate inhibitory neuron was blocked by CNQX (an antagonist of the AMPA subtype of glutamate receptor). Based on these and prior studies, it seems likely that the effects of hippocampal formation stimulation are mediated by feed-forward inhibition, in which GABAergic amygdaloid inhibitory neurons are excited by glutamatergic projections from the hippocampal formation. the effects of basal forebrain stimulation may be mediated by both feed-forward inhibition and direct, GABAergic inhibition.
Palavra-chave LIMBIC SYSTEM
INHIBITORY NEURON
NEURAL NETWORK
DIAGONAL BAND
VENTRAL PALLIDUM
SUBSTANTIA INNOMINATA
SUBICULAR COMPLEX
ENTORHINAL CORTEX
SYNAPTIC POTENTIAL
GLUTAMATE
DENTATE GYRUS
Idioma Inglês
Data de publicação 1992-07-31
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 587, n. 1, p. 41-48, 1992.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 41-48
Fonte http://dx.doi.org/10.1016/0006-8993(92)91426-F
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1992JK14000004
Endereço permanente http://repositorio.unifesp.br/handle/11600/25268

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