GABAERGIC SYNAPTIC TRANSMISSION in PROJECTIONS FROM the BASAL FOREBRAIN and HIPPOCAMPAL-FORMATION TO the AMYGDALA - AN INVIVO IONTOPHORETIC STUDY

GABAERGIC SYNAPTIC TRANSMISSION in PROJECTIONS FROM the BASAL FOREBRAIN and HIPPOCAMPAL-FORMATION TO the AMYGDALA - AN INVIVO IONTOPHORETIC STUDY

Author Mello, LEAM Google Scholar
Tan, A. M. Google Scholar
Finch, D. M. Google Scholar
Institution UNIV CALIF LOS ANGELES
Universidade Federal de São Paulo (UNIFESP)
Abstract We recorded extracellular responses from rat amygdaloid neurons in vivo after electrical stimulation of the basal forebrain and hippocampal formation. Iontophoretic application of the GABA(A) receptor antagonist, bicuculline, lead to the appearance of short latency evoked bursts after stimulation of either region. This occurred whether the baseline response was inhibitory or excitatory. Bicuculline only affected an early phase of inhibition, leaving a longer latency, longer duration phase unchanged or even increased. By contrast, the GABA(B) receptor antagonist, phaclofen, never produced such short latency evoked bursts. Both bicuculline and phaclofen increased the spontaneous rate of firing of amygdaloid neurons. the excitatory burst response to hippocampal formation stimulation of an amygdaloid candidate inhibitory neuron was blocked by CNQX (an antagonist of the AMPA subtype of glutamate receptor). Based on these and prior studies, it seems likely that the effects of hippocampal formation stimulation are mediated by feed-forward inhibition, in which GABAergic amygdaloid inhibitory neurons are excited by glutamatergic projections from the hippocampal formation. the effects of basal forebrain stimulation may be mediated by both feed-forward inhibition and direct, GABAergic inhibition.
Keywords LIMBIC SYSTEM
INHIBITORY NEURON
NEURAL NETWORK
DIAGONAL BAND
VENTRAL PALLIDUM
SUBSTANTIA INNOMINATA
SUBICULAR COMPLEX
ENTORHINAL CORTEX
SYNAPTIC POTENTIAL
GLUTAMATE
DENTATE GYRUS
Language English
Date 1992-07-31
Published in Brain Research. Amsterdam: Elsevier B.V., v. 587, n. 1, p. 41-48, 1992.
ISSN 0006-8993 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 41-48
Origin http://dx.doi.org/10.1016/0006-8993(92)91426-F
Access rights Closed access
Type Article
Web of Science ID WOS:A1992JK14000004
URI http://repositorio.unifesp.br/handle/11600/25268

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account