PREGNANT-WOMEN WITH ENDEMIC PEMPHIGUS FOLIACEUS (FOGO SELVAGEM) GIVE BIRTH TO DISEASE-FREE BABIES

PREGNANT-WOMEN WITH ENDEMIC PEMPHIGUS FOLIACEUS (FOGO SELVAGEM) GIVE BIRTH TO DISEASE-FREE BABIES

Autor Alvarez, Rosicler Rocha Aiza Autor UNIFESP Google Scholar
Friedman, Horácio Google Scholar
Campbell, Iphis T. Google Scholar
Souza-Aguiar, Ligia Google Scholar
Castro, Raymundo Martins de Autor UNIFESP Google Scholar
Diaz, Luis A. Google Scholar
Instituição MED COLL WISCONSIN
Universidade Federal de São Paulo (UNIFESP)
Universidade de Brasília (UnB)
Resumo Endemic pemphigus foliaceus (PF), also known as Fogo Selvagem (FS), is an organ-specific autoimmune disease mediated by autoantibodies. These autoantibodies are disease specific, predominantly restricted to the IgG4 subclass, and pathogenic, as demonstrated by passive transfer studies. in contrast to pemphigus vulgaris, neonatal skin disease does not appear to occur in babies born to mothers with non-endemic PF or FS. in the present study we have examined 19 mother/neonate pairs where the mother had documented FS. Mothers and neonates were examined soon after delivery and tested by immunofluorescent (IF) techniques for FS autoantibodies either in circulation (mothers' sera or babies' cord blood) or bound to the neonatal epidermis. All neonates included in this study were born with normal skin. Twelve biopsies from 17 neonates showed negative direct IF using both FITC-antihuman IgG or monoclonal anti-IgG subclass antibodies. in five biopsies the epidermal ICS of the babies showed weak staining. in 10 of the 19 cord sera tested, FS IgG autoantibodies were undetectable; in nine, these autoantibodies were present in low titers (< 1 : 40). the sera of the mothers showed higher titers of FS autoantibodies, and IgG4 was the predominant IgG subclass autoantibodies. It appears that human placenta may modulate the expression of disease in the newborn by operating as a biologic immunoadsorbent of pathogenic autoantibodies.
Idioma Inglês
Data de publicação 1992-07-01
Publicado em Journal of Investigative Dermatology. Malden: Blackwell Science Inc, v. 99, n. 1, p. 78-82, 1992.
ISSN 0022-202X (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Science Inc
Extensão 78-82
Fonte http://dx.doi.org/10.1111/1523-1747.ep12611868
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1992JB43700013
Endereço permanente http://repositorio.unifesp.br/handle/11600/25259

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