AGE-RELATED ANTICONVULSANT ACTIVITY of NMDA in the RAT CAUDATE-PUTAMEN

AGE-RELATED ANTICONVULSANT ACTIVITY of NMDA in the RAT CAUDATE-PUTAMEN

Autor Cavalheiro, E. A. Google Scholar
Defeo, M. R. Google Scholar
Mecarelli, O. Google Scholar
Ricci, G. Google Scholar
Instituição UNIV LA SAPIENZA
Universidade Federal de São Paulo (UNIFESP)
Resumo Striatal pathways are important for modulating the threshold for seizures in the rat forebrain. N-Methyl-D-aspartate (NMDA), an excitatory amino acid derivative and powerful anticonvulsant agent, when injected into the brain, has been shown to protect adult rats against kindling and pilocarpine-induced seizures when injected into the caudate-putamen. the present study examines whether the anticonvulsant action of NMDA in the caudate-putamen varies with age. Bilateral striatal administration of NMDA was effective in suppressing bicuculline-induced seizures in rats older than 23 days of age. the results suggest that striatal pathways involved in the anticonvulsant activity of NMDA in the caudate-putamen are not functionally active in developing rats before the 4th week of life.
Palavra-chave BASAL GANGLIA
N-METHYL-D-ASPARTATE
BICUCLLINE
SEIZURE
EPILEPSY
DEVELOPMENT
Idioma Inglês
Data de publicação 1992-06-19
Publicado em Developmental Brain Research. Amsterdam: Elsevier B.V., v. 67, n. 2, p. 371-374, 1992.
ISSN 0165-3806 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 371-374
Fonte http://dx.doi.org/10.1016/0165-3806(92)90237-Q
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1992JE10400026
Endereço permanente http://repositorio.unifesp.br/handle/11600/25258

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