AGE DEPENDENCY of the SUSCEPTIBILITY of RATS TO AMINOOXYACETIC ACID SEIZURES

AGE DEPENDENCY of the SUSCEPTIBILITY of RATS TO AMINOOXYACETIC ACID SEIZURES

Autor Turski, W. Google Scholar
Dziki, M. Google Scholar
Parada, J. Google Scholar
Kleinrok, Z. Google Scholar
Cavalheiro, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats. Highest susceptibility to AOAA seizures was observed in 7-14-day-old rat pups. the lowest susceptibility was recorded in 10-20 month-old rats. AOAA seizures in 14-day-old rats were blocked by clonazepam and valproate, but not by phenobarbital, carbamazepine, diphenylhydantoin, trimethadione or ethosuximide. Morphological analysis of brains from 14-day- and 3-month-old rats which experienced AOAA seizures did not reveal epilepsy-related damage. These observations suggest that immature rat brain is highly prone to convulsions induced by AOAA and that such convulsions are difficult to control by available antiepileptic treatment.
Palavra-chave AMINOOXYACETIC ACID
SEIZURE
ANTIEPILEPTIC DRUG
DEVELOPMENT
RAT
Idioma Inglês
Data de publicação 1992-06-19
Publicado em Developmental Brain Research. Amsterdam: Elsevier B.V., v. 67, n. 2, p. 137-144, 1992.
ISSN 0165-3806 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 137-144
Fonte http://dx.doi.org/10.1016/0165-3806(92)90214-H
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1992JE10400003
Endereço permanente http://repositorio.unifesp.br/handle/11600/25257

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta