QUANTITATION of RED CELL-BOUND IGG BY AN ENZYME-LINKED ANTIGLOBULIN-TEST in HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PERSONS

QUANTITATION of RED CELL-BOUND IGG BY AN ENZYME-LINKED ANTIGLOBULIN-TEST in HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PERSONS

Autor Bordin, J. O. Google Scholar
Kerbauy, J. Google Scholar
Souza-Pinto, José Carlos Autor UNIFESP Google Scholar
Conti, E. Google Scholar
Accetturi, C. A. Google Scholar
Kishiwada, MAM Google Scholar
Novo, N. F. Google Scholar
Castelo, A. Google Scholar
Instituição HOSP SERVIDOR PUBL MUNICIPAL
Universidade Federal de São Paulo (UNIFESP)
Resumo Anemia, thrombocytopenia, and neutropenia have been observed in patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex. To investigate whether red cell (RBCs) of patients with human immunodeficiency virus infection were coated with IgG and/or complement (C3), blood samples of 239 patients were tested. the prevalence of a positive direct antiglobulin test on RBCs was 16.7 percent. By use of an enzyme-linked antiglobulin test (ELAT) to measure more accurately the number of IgG molecules per RBC in a group of 67 patients, 30 of the 67 individuals were observed to have increased numbers (mean, 155) compared to normal control and to patients with hypergammaglobulinemia due to multiple myeloma or chronic liver disease. Hemoglobin level was correlated with the number of IgG molecules per RBC (p = .008), but no correlation could be demonstrated between those numbers and serum immunoglobulin (p = 0.10) or circulating immune complexes (p = 0.38). Our results with ELAT suggest that some AIDS patients may have specific binding of IgG on the surface of their RBCs, rather than nonspecific uptake; further clinical correlations are necessary to confirm these findings.
Idioma Inglês
Data de publicação 1992-06-01
Publicado em Transfusion. Bethesda: Amer Assoc Blood Banks, v. 32, n. 5, p. 426-429, 1992.
ISSN 0041-1132 (Sherpa/Romeo, fator de impacto)
Publicador Amer Assoc Blood Banks
Extensão 426-429
Fonte http://dx.doi.org/10.1046/j.1537-2995.1992.32592327715.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1992JB60600008
Endereço permanente http://repositorio.unifesp.br/handle/11600/25254

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