EFFECTS of ENDOTHELIN-3 ON the ISOLATED GUINEA-PIG ILEUM - ROLE of NA+ IONS and ENDOTHELIN RECEPTOR SUBTYPES

EFFECTS of ENDOTHELIN-3 ON the ISOLATED GUINEA-PIG ILEUM - ROLE of NA+ IONS and ENDOTHELIN RECEPTOR SUBTYPES

Autor Miasiro, N. Google Scholar
Paiva, ACM Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Endothelin-3 induced a relaxation followed by contraction in the isolated guinea-pig ileum. the contractile but not the relaxant component of the response was concentration-dependent in the dose range studied. Neuronal mechanisms, cyclic GMP and ATP-dependent K+ channels are not involved in the relaxing effect since this component was not affected by either tetrodotoxin, methylene blue or glibenclamide. Endothelin-3 induced tachyphylaxis (homologous desensitization) that was not fully reversed after a 3-h resting period. the responses were inhibited in low-Na+ medium or after treatment with ouabain. Verapamil affected both the relaxant and the contractile components of the response, and phorbol-12,13-dibutyrate affected mainly the contractile component. Cross-tachyphylaxis studies between endothelin-1 and endothelin-3 suggest the existence of at least two endothelin receptor subtypes (or different ligand-receptor complexes) in the guinea-pig ileum.
Palavra-chave ENDOTHELIN-3
ENDOTHELIN-1
ILEUM (GUINEA-PIG)
DESENSITIZATION
NA+ IONS
ENDOTHELIN RECEPTOR SUBTYPES
Idioma Inglês
Data de publicação 1992-04-22
Publicado em European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 214, n. 2-3, p. 133-141, 1992.
ISSN 0014-2999 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 133-141
Fonte http://dx.doi.org/10.1016/0014-2999(92)90110-P
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1992HT71500004
Endereço permanente http://repositorio.unifesp.br/handle/11600/25249

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