INVITRO ACTIVITY of OPC-17116 COMPARED TO OTHER BROAD-SPECTRUM FLUOROQUINOLONES

INVITRO ACTIVITY of OPC-17116 COMPARED TO OTHER BROAD-SPECTRUM FLUOROQUINOLONES

Autor Sader, H. S. Google Scholar
Erwin, M. E. Google Scholar
Jones, R. N. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The in vitro activity of OPC-17116 was compared to that of rive similar fluoroquinolones (ciprofloxacin, enoxacin, norfloxacin, ofloxacin and temafloxacin). A total of 700 isolates from recent cases of clinical bacteremia were tested. Fifty additional stock strains with well-characterized resistance mechanisms were also processed. the minimal concentrations inhibiting 90 % of strains (MIC90) of Enterobacteriaceae species were for OPC-17116 0.015-0.5-mu-g/ml and for ciprofloxacin 0.015-0.25-mu-g/ml. Moraxella catarrhalis, Haemophilus influenzae and Neisseria gonorrhoeae were very susceptible to OPC-17116 (MIC90 0.015-mu-g/ml) thus being fourfold more active than ciprofloxacin. for all beta-hemolytic streptococci and pneumococci OPC-17116 MICs were less-than-or-equal-to 0.5-mu-g/ml. the most resistant enteric bacilli were among the Citrobacter freundii and Providencia rettgeri strains (MIC90 0.5-mu-g/ml). Pseudomonas aeruginosa strains were comparably susceptible to OPC-17116 (MIC90 0.5-mu-g/ml). Low pH and CO2 incubation had an adverse effect on OPC-17116 MICs, and resistance development was documented among current clinical isolates of staphylococci, pseudomonas and some Enterobacteriaceae.
Idioma Inglês
Data de publicação 1992-04-01
Publicado em European Journal of Clinical Microbiology & Infectious Diseases. Wiesbaden 1: Friedr Vieweg Sohn Verlag Gmbh, v. 11, n. 4, p. 372-381, 1992.
ISSN 0934-9723 (Sherpa/Romeo, fator de impacto)
Publicador Friedr Vieweg Sohn Verlag Gmbh
Extensão 372-381
Fonte http://dx.doi.org/10.1007/BF01962081
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1992HY37200015
Endereço permanente http://repositorio.unifesp.br/handle/11600/25247

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