LUNG and MYOCARDIAL TL-201 KINETICS in RESTING PATIENTS WITH CONGESTIVE-HEART-FAILURE - CORRELATION WITH PULMONARY CAPILLARY WEDGE PRESSURE

LUNG and MYOCARDIAL TL-201 KINETICS in RESTING PATIENTS WITH CONGESTIVE-HEART-FAILURE - CORRELATION WITH PULMONARY CAPILLARY WEDGE PRESSURE

Autor Martinez, E. E. Google Scholar
Horowitz, S. F. Google Scholar
Castello, H. J. Google Scholar
Castiglioni, MLV Google Scholar
Carvalho, ACC Google Scholar
Almeida, D. R. Google Scholar
Roberti, R. R. Google Scholar
Saragoca, M. A. Google Scholar
Barbieri, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
BETH ISRAEL MED CTR
Resumo Increased lung thallium-201 activity occurs with exercise in patients with severe coronary artery disease as a result of increased pulmonary capillary wedge pressure. No study has shown resting lung kinetics in chronic congestive heart failure. To better understand the relationship between lung and myocardial thallium uptake and pulmonary capillary wedge pressure, this study was performed. Resting lung and myocardial thallium uptake, expressed as a ratio, were compared with simultaneous pulmonary capillary wedge pressure in 16 patients with congestive heart failure and cardiomyopathy, all New York Heart Association class IV. There were no variations in pulmonary capillary wedge pressure throughout the study protocol. There was a significant reduction in the lung/myocardium thallium ratio from 10 to 60 minutes (0.83 +/- 0.30 to 0.59 +/- 0.17; p < 0.001). At 60 minutes after thallium injection there was a linear correlation between the lung/myocardium ratio and capillary wedge pressure with an r value of 0.62 (p < 0.01). Thus thallium-201 washout is rapid despite persistence of pulmonary capillary wedge pressure elevation, indicating that clearance does not imply resolution of congestive heart failure. in addition, a significant but imprecise correlation was found between capillary pressure and the lung/myocardium ratio. Rapid changes in lung activity during the early postinjection period may limit the clinical use of the lung/myocardium ratio.
Idioma Inglês
Data de publicação 1992-02-01
Publicado em American Heart Journal. St Louis: Mosby-year Book Inc, v. 123, n. 2, p. 427-432, 1992.
ISSN 0002-8703 (Sherpa/Romeo, fator de impacto)
Publicador Mosby-year Book Inc
Extensão 427-432
Fonte http://dx.doi.org/10.1016/0002-8703(92)90657-H
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1992HC25800023
Endereço permanente http://repositorio.unifesp.br/handle/11600/25241

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